The RCMI Program in Health Disparities Research at Meharry Medical College (RHDR@MMC) proposes to address health disparities at multiples scales of research: from micro to macro environments. With institutional collaboration and support, this application continues the long-term RCMI support of enabling high quality basic, behavioral, and clinical research to eliminate health disparities as our long-term goal. The RHDR@MMC is not discipline or disease focused, but emphasizes the disruption of disparity at all scales, from proteins to the human ecosystems of the populations we serve. Our re-envisioned Research Infrastructure Core will provide expert technical support in areas relevant to the research projects, as well as services such as design, biostatistics, bio and health informatics, and cross-training support to benefit ALL researchers at the institution. We have assembled a cadre of scientists including basic, behavioral, dental clinicians, population-based, and community-engaged researchers at Meharry to participate in this endeavor.
Our aims are to: 1. Support four outstanding research projects addressing HIV-AIDS, prostate cancer, racial and ethnic differences in periodontal disease microbiomes, and adversity-driven chronic pain to advance fundamental understanding of these health disparities. 2. Strengthen core technologies and expand bioinformatics and biostatistical services supporting the four research projects, as well as all Meharry research faculty, to increase institutional success in extramural funding studying diseases that disproportionally affect minority and other health disparity populations. 3. Nurture an environment conducive to developing new and early career investigators by facilitating a mentorship network, enhancing professional developmental activities, and providing pilot project funds. 4. Improve and expand relationships with community-based organizations that partner with Meharry. 5. Recruit outstanding magnet scientists to energize current faculty and contribute to our research capacity in cancers of the underserved, infectious diseases including HIV-AIDS, disparity-causing differences in microbiomes of minorities, and societal adversity leading to debilitating chronic pain in African Americans.

Public Health Relevance

The RCMI Program in Health Disparities Research is designed to address health disparities through research in diseases that affect the community it serves, engagement of this community in its solutions, and creating technologies and research infrastructure to serve the institutional scientific community and its academic and community partners. This collaborative approach is critical because finding the right answers to address disparities in health equity involves all of us.

Agency
National Institute of Health (NIH)
Institute
National Institute on Minority Health and Health Disparities (NIMHD)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54MD007586-32
Application #
9569282
Study Section
Special Emphasis Panel (ZMD1)
Program Officer
Das, Rina
Project Start
1997-09-30
Project End
2022-06-30
Budget Start
2018-07-01
Budget End
2019-06-30
Support Year
32
Fiscal Year
2018
Total Cost
Indirect Cost
Name
Meharry Medical College
Department
Type
Graduate Schools
DUNS #
041438185
City
Nashville
State
TN
Country
United States
Zip Code
37208
Warren Andersen, Shaneda; Blot, William J; Shu, Xiao-Ou et al. (2018) Associations Between Neighborhood Environment, Health Behaviors, and Mortality. Am J Prev Med 54:87-95
Bailey, Brooklynn; Morris, Matthew C (2018) Longitudinal Associations Among Negative Cognitions and Depressive and Posttraumatic Stress Symptoms in Women Recently Exposed to Stalking. J Interpers Violence :886260518807905
Zhang, Lin; Hu, Wei; Cho, Chi H et al. (2018) Reduced lysosomal clearance of autophagosomes promotes survival and colonization of Helicobacter pylori. J Pathol 244:432-444
Walker, Miriam Y; Pratap, Siddharth; Southerland, Janet H et al. (2018) Role of oral and gut microbiome in nitric oxide-mediated colon motility. Nitric Oxide 73:81-88
Xie, Yingqiu; Fan, Haiyan; Lu, Wenfu et al. (2018) Nuclear MET requires ARF and is inhibited by carbon nanodots through binding to phospho-tyrosine in prostate cancer. Oncogene :
Archibong, Anthony E; Rideout, Meredith L; Harris, Kenneth J et al. (2018) OXIDATIVE STRESS IN REPRODUCTIVE TOXICOLOGY. Curr Opin Toxicol 7:95-101
Smith Jr, Joseph T; Singha, Ujjal K; Misra, Smita et al. (2018) Divergent Small Tim Homologues Are Associated with TbTim17 and Critical for the Biogenesis of TbTim17 Protein Complexes in Trypanosoma brucei. mSphere 3:
McIntosh, Deneshia J; Walters, Treniqka S; Arinze, Ifeanyi J et al. (2018) Arkadia (RING Finger Protein 111) Mediates Sumoylation-Dependent Stabilization of Nrf2 Through K48-Linked Ubiquitination. Cell Physiol Biochem 46:418-430
Choi, Wonyoung; Kim, Jeongsik; Park, Jaeoh et al. (2018) YAP/TAZ Initiates Gastric Tumorigenesis via Upregulation of MYC. Cancer Res 78:3306-3320
Mimura, Kousaku; Teh, Jun Liang; Okayama, Hirokazu et al. (2018) PD-L1 expression is mainly regulated by interferon gamma associated with JAK-STAT pathway in gastric cancer. Cancer Sci 109:43-53

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