The Puerto Rico Clinical and Translational Research Consortium (PRCTRC) is an innovative model of collaboration, bringing together and leveraging the intellectual and physical resources of three major medical and health science centers in Puerto Rico: The University of Puerto Rico Medical Sciences Campus (UPRMSC), the Universidad del Caribe Central (UCC), and the Ponce School of Medicine &Health Sciences (PSM&HS) to address and reduce health disparities that most impact Hispanic populations. The mission is to serve as a vital and catalytic element in the efforts to understand, define, and address health disparities in Hispanic populations. Our efforts are guided by four strategic goals: 1) Facilitate the generation and translation of knowledge from the bench into the community by establishing a centralized program focused on reducing health disparities among Hispanic populations;2) Enhance and support existing training and mentoring programs to increase the number of new minority investigators in Clinical and Translational Research;3) Encourage collaborations among basic, clinical, and social scientists and community networks and health programs;and 4) Enhance and integrate existing infrastructure for clinical and translational research across Puerto Rico to support and expand Clinical and Translational Research in health disparities The PRCTRC has fostered a synergistic environment that supports research across the clinical and translational research continuum, with an emphasis on four disease states that post the greatest threats to Hispanic health: HIV/AIDS, neurological diseases, cardiovascular and metabolic diseases, and cancer. The PRCTRC provides this integrated infrastructure to investigators through nine Cores: Regulatory Knowledge and Support, Research Design and Biostatistics, clinical Research Resources and Facilities, Technology Resources for Core Laboratories, Biomedical Informatics, Collaborations and Partnerships, Professional Development, Clinical and Translational Pilot Project Program, and Community-based Research. Oversight is provided by an Administrative Core and formative and summative evaluation is provided by an Evaluation Core.

Public Health Relevance

Health disparities among underrepresented minorities constitute an important public health problem. This project proposes to generate important knowledge about the underlying causes and the most effective methods to reduce these health disparities among Hispanics. This project will also increase the participation of underrepresented minority investigators working on this problem.

Agency
National Institute of Health (NIH)
Institute
National Institute on Minority Health and Health Disparities (NIMHD)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
2U54MD007587-04
Application #
8754896
Study Section
Special Emphasis Panel (ZMD1)
Program Officer
Zhang, Xinzhi
Project Start
2010-09-17
Project End
2019-04-30
Budget Start
2014-07-15
Budget End
2015-04-30
Support Year
4
Fiscal Year
2014
Total Cost
Indirect Cost
Name
University of Puerto Rico Med Sciences
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
City
San Juan
State
PR
Country
United States
Zip Code
00936
Ortiz-Ortiz, Karen J; Tortolero-Luna, Guillermo; Ríos-Motta, Ruth et al. (2018) Use of adjuvant chemotherapy in patients with stage III colon cancer in Puerto Rico: A population-based study. PLoS One 13:e0194415
Morales-Ortíz, Jessica; Deal, Victoria; Reyes, Fiorella et al. (2018) Platelet-derived TLT-1 is a prognostic indicator in ALI/ARDS and prevents tissue damage in the lungs in a mouse model. Blood 132:2495-2505
Gonzalez, Velda J; McMillan, Susan; Pedro, Elsa et al. (2018) The Health related Quality of Life of Puerto Ricans during Cancer Treatments; A Pilot Study. P R Health Sci J 37:46-51
Rosario-Rodríguez, Lester J; Colón, Krystal; Borges-Vélez, Gabriel et al. (2018) Dimethyl Fumarate Prevents HIV-Induced Lysosomal Dysfunction and Cathepsin B Release from Macrophages. J Neuroimmune Pharmacol :
Elion, Richard A; Althoff, Keri N; Zhang, Jinbing et al. (2018) Recent Abacavir Use Increases Risk of Type 1 and Type 2 Myocardial Infarctions Among Adults With HIV. J Acquir Immune Defic Syndr 78:62-72
Ortiz, A P; Tortolero-Luna, G; Romaguera, J et al. (2018) Seroprevalence of HPV 6, 11, 16 and 18 and correlates of exposure in unvaccinated women aged 16-64 years in Puerto Rico. Papillomavirus Res 5:109-113
Gonzalez, Velda J; Abbas-Aghababazadeh, Farnoosh; Fridley, Brooke L et al. (2018) Expression of Sestrin Genes in Radiotherapy for Prostate Cancer and Its Association With Fatigue: A Proof-of-Concept Study. Biol Res Nurs 20:218-226
Marqués-Lespier, Juan M; Soto-Salgado, Marievelisse; González-Pons, María et al. (2018) Prevalence of Synchronous Oligopolyposis in Incident Colorectal Cancer: A Population-Based Study. P R Health Sci J 37:39-45
Colón-Cruz, Luis; Kristofco, Lauren; Crooke-Rosado, Jonathan et al. (2018) Alterations of larval photo-dependent swimming responses (PDR): New endpoints for rapid and diagnostic screening of aquatic contamination. Ecotoxicol Environ Saf 147:670-680
Pereira-Morales, Sherily; Arroyo-Novoa, Carmen Mabel; Wysocki, Annette et al. (2018) Acute Pain Assessment in Sedated Patients in the Postanesthesia Care Unit. Clin J Pain 34:700-706

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