The overarching goal of the proposed Biostatistical and Epidemiologic Methods Core (Methods Core) is to foster collaborative, interdisciplinary research and apply novel research strategies to improve health outcomes and reduce health disparities among vulnerable populations and underserved communities. The Core supports and facilitates the development and implementation of methodologically sound and culturally appropriate clinical and translational investigations aimed at the reduction of health disparities. Researchers from five disciplines (epidemiology, biostatistics, health services research, sociology, and medicine) bring a diversity of research methodologies and conceptual frameworks to collaborative scholarship on the health and well-being of the diverse communities. Many of the chronic diseases that are so prevalent in South Los Angeles community where CDU is located and are pressing health concerns for the nation. The Methods Core will be a catalyst for translational research approaches among AXIS cores, community partners, and other health scientists at the University and across partnering institutions. In addition to the traditional research design and biostatistical support currently provided for clinical and translational investigators in collaboration with CTSI and RTRN, the following specific aims are being proposed to expand the research infrastructure at the University:
Specific Aim 1 : To provide comprehensive consultation and education/training in clinical and translational research methods and biostatistics to University researchers.
Specific Aim 2 : To enhance the institutional capacity to perform secondary database research

Public Health Relevance

The Core supports and facilitates the development and implementation of methodologically sound and culturally appropriate clinical and translational investigations aimed at the reduction of health disparities.

Agency
National Institute of Health (NIH)
Institute
National Institute on Minority Health and Health Disparities (NIMHD)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54MD007598-10
Application #
9471241
Study Section
Special Emphasis Panel (ZMD1)
Project Start
Project End
Budget Start
2018-05-01
Budget End
2019-04-30
Support Year
10
Fiscal Year
2018
Total Cost
Indirect Cost
Name
Charles R. Drew University of Medicine & Science
Department
Type
DUNS #
785877408
City
Los Angeles
State
CA
Country
United States
Zip Code
90059
Hasan, Mohammad Kamrul; Friedman, Theodore C; Sims, Carl et al. (2018) ?7-Nicotinic Acetylcholine Receptor Agonist Ameliorates Nicotine Plus High-Fat Diet-Induced Hepatic Steatosis in Male Mice by Inhibiting Oxidative Stress and Stimulating AMPK Signaling. Endocrinology 159:931-944
Elsaid, Ahmed F; Shaheen, Magda; Ghoneum, Mamdooh (2018) Biobran/MGN-3, an arabinoxylan rice bran, enhances NK cell activity in geriatric subjects: A randomized, double-blind, placebo-controlled clinical trial. Exp Ther Med 15:2313-2320
Sinha-Hikim, Amiya P; Mahata, Sushil K (2018) Editorial: Obesity, Smoking, and Fatty Liver Disease. Front Endocrinol (Lausanne) 9:1
Chung, Seyung S; Dutta, Pranabananda; Austin, David et al. (2018) Combination of resveratrol and 5-flurouracil enhanced anti-telomerase activity and apoptosis by inhibiting STAT3 and Akt signaling pathways in human colorectal cancer cells. Oncotarget 9:32943-32957
Schwartz, Steven; Bazargan-Hejazi, Shahrzad; Pan, Deyu et al. (2018) Association of Psychiatric Diagnostic Conditions with Hospital Care Outcomes of Patients with Orthopedic Injuries. Perm J 22:
Jenders, Robert A; Adlassnig, Klaus-Peter; Fehre, Karsten et al. (2018) Evolution of the Arden Syntax: Key Technical Issues from the Standards Development Organization Perspective. Artif Intell Med 92:10-14
Maxwell, Annette E; Castillo, Laura; Arce, Anthony A et al. (2018) Eating Veggies Is Fun! An Implementation Pilot Study in Partnership With a YMCA in South Los Angeles. Prev Chronic Dis 15:E132
Elshimali, Yahya I; Wu, Yong; Khaddour, Hussein et al. (2018) Optimization Of Cancer Treatment Through Overcoming Drug Resistance. J Cancer Res Oncobiol 1:
Hanuscin, Chris; Zahmatkesh, Golara; Shirazi, Anaheed et al. (2018) Socio-Demographic and Mental Health Profile of Admitted Cases of Self-Inflicted Harm in the US Population. Int J Environ Res Public Health 15:
La, V; Fujikawa, R; Janzen, D M et al. (2017) Birinapant sensitizes platinum-resistant carcinomas with high levels of cIAP to carboplatin therapy. NPJ Precis Oncol 1:

Showing the most recent 10 out of 190 publications