D8.2 Administration and Management: The TSRI Center will be administered by the PI in consultation withthe Center Screening Committee. The functional cores (Assay Implementation, uHTS Implementation,Informatics, PK, Chemistry and QA) will meet on a monthly basis to set goals and metrics towards thoseinterim goals, as well as monitor progress towards the global Specific Aims with their timed milestones.Variances of > 1 Quarter from the planned global milestones will be flagged by the PI and brought to theattention of the CSC. Remedial steps will be taken in real time to solve the specific problems. Should the PI, inconsultation with the CSC, identify variances that, after remedial steps have been taken, still impact on scopeor timeliness of deliverables, the PI will draw this to the attention of NIH staff where appropriate and seekguidance. In addition to the successful implementation ahead of time and on budget of the MLSCN Center andchairing the MLSCN Steering Group, the PI had significant therapeutic area head level industrial experience atMerck. It is well within his capabilities to define key Center problems and lead them to resolution at theappropriate level within the Center or the NIH Project Team. Integration of Assay Development, Adaptation anduHTS implementation is managed by the monthly meeting of the Screening Coordination Committee (SCC).
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