Abstract

The vision of JHICC center-driven research is to perform projects that have an immediate impact on ion channel probe development and offer high value for the research activities of other Centers. This will greatly benefit the overall NIH-Molecular Library Programs (MLP). Here we propose two projects. The first project focuses on technology development. Specifically, we propose to develop cell-based label-free detection of ion channel and receptor activities. The second project focuses on a comprehensive service function by providing a high-level technical evaluation to predict compound cardiotoxicity. These two projects take advantage of our own expertise and should provide immediate benefit to both our own effort and the overall program of NIH network centers. 1. Cell-based label-free detection of ion channel and receptor activitiesrs. 2. Cardiac toxicity screen to evaluate compounds

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54MH084691-03
Application #
8117303
Study Section
Special Emphasis Panel (ZRG1)
Project Start
2010-06-01
Project End
2014-05-31
Budget Start
2010-06-01
Budget End
2011-05-31
Support Year
3
Fiscal Year
2010
Total Cost
$132,000
Indirect Cost

  Institution

Name
Johns Hopkins University
Department
Type
DUNS #
001910777
City
Baltimore
State
MD
Country
United States
Zip Code
21218

  Publications

Agoulnik, Alexander I; Agoulnik, Irina U; Hu, Xin et al. (2017) Synthetic non-peptide low molecular weight agonists of the relaxin receptor 1. Br J Pharmacol 174:977-989
Wu, Ying; Zou, Beiyan; Liang, Lingli et al. (2017) Loperamide inhibits sodium channels to alleviate inflammatory hyperalgesia. Neuropharmacology 117:282-291
Qu, Chunrong; Ding, Mingmin; Zhu, Yingmin et al. (2017) Pyrazolopyrimidines as Potent Stimulators for Transient Receptor Potential Canonical 3/6/7 Channels. J Med Chem 60:4680-4692
Yu, Hai-bo; Zou, Bei-yan; Wang, Xiao-liang et al. (2016) Investigation of miscellaneous hERG inhibition in large diverse compound collection using automated patch-clamp assay. Acta Pharmacol Sin 37:111-23
Sun, Han; Luo, Liqun; Lal, Bachchu et al. (2016) A monoclonal antibody against KCNK9 K(+) channel extracellular domain inhibits tumour growth and metastasis. Nat Commun 7:10339
Schreiber, Stuart L; Kotz, Joanne D; Li, Min et al. (2015) Advancing Biological Understanding and Therapeutics Discovery with Small-Molecule Probes. Cell 161:1252-65
Zhu, Yingmin; Lu, Yungang; Qu, Chunrong et al. (2015) Identification and optimization of 2-aminobenzimidazole derivatives as novel inhibitors of TRPC4 and TRPC5 channels. Br J Pharmacol 172:3495-509
Li, Weiqiang; Koutmou, Kristin S; Leahy, Daniel J et al. (2015) Systemic RNA Interference Deficiency-1 (SID-1) Extracellular Domain Selectively Binds Long Double-stranded RNA and Is Required for RNA Transport by SID-1. J Biol Chem 290:18904-13
Yu, Haibo; Zou, Beiyan; Wang, Xiaoliang et al. (2015) Effect of tyrphostin AG879 on Kv 4.2 and Kv 4.3 potassium channels. Br J Pharmacol 172:3370-82
Du, Fang; Babcock, Joseph J; Yu, Haibo et al. (2015) Global analysis reveals families of chemical motifs enriched for HERG inhibitors. PLoS One 10:e0118324

Showing the most recent 10 out of 60 publications