The long-term goal of this proposal is to develop a strong Neuroscience Research Program (SRNP) at Hunter College by bringing together a strong core of Neuroscientists with similar research interests. It is envisaged that the theme of this Neuroscience Program will be """"""""Repairing the Damaged Nervous System"""""""". A core of molecular/cellular Neurobiologists will be established, with similar, complementary interests in topics such as neuronal death and survival, axonal regeneration and guidance during development, and myelination, both during development and after disease/injury. By developing this theme in Neuroscience the strengths already at Hunter College will be built upon and expanded.
The specific aims of this proposal are:
Aim #1 : To strengthen the general research theme of """"""""Repairing the Damaged Nervous System"""""""" through 3 related projects, which in year 3 of the proposal will be submitted as R01s. It is of note that aspects of these projects are translational and related to health disparities Aim #2: To strengthen and expand technology and its sharing and to promote collaborations via a viral vector core, an electrophysiology core and shared models of regeneration.
Aim #3 : To develop a sub-theme of Neuroscience within the Biology Department of Hunter College. Funding of this proposal will also allow more outside speakers to be invited to give seminars on Neuroscience. A strong Neuroscience Research Program will also (a) expose undergraduates to Neuroscience at a very early stage of their career and so stimulate an interest in;neuroscience, (b) provide graduate students with more Neuroscience labs to choose from for their PhD research. New ideas would be stimulated and they would be exposed to a variety of state-of-the-art techniques and (c) attract strong post-doctoral fellows.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
3U54NS041073-10S1
Application #
8150187
Study Section
Special Emphasis Panel (ZNS1-SRB-P (17))
Program Officer
Gordon, Alfred W
Project Start
2000-09-30
Project End
2013-08-31
Budget Start
2010-09-01
Budget End
2013-08-31
Support Year
10
Fiscal Year
2010
Total Cost
$1,100,000
Indirect Cost
Name
Hunter College
Department
Biology
Type
Schools of Arts and Sciences
DUNS #
620127915
City
New York
State
NY
Country
United States
Zip Code
10065
Kiprowska, Magdalena J; Stepanova, Anna; Todaro, Dustin R et al. (2017) Neurotoxic mechanisms by which the USP14 inhibitor IU1 depletes ubiquitinated proteins and Tau in rat cerebral cortical neurons: Relevance to Alzheimer's disease. Biochim Biophys Acta Mol Basis Dis 1863:1157-1170
He, Huifang; Deng, Kangwen; Siddiq, Mustafa M et al. (2016) Cyclic AMP and Polyamines Overcome Inhibition by Myelin-Associated Glycoprotein through eIF5A-Mediated Increases in p35 Expression and Activation of Cdk5. J Neurosci 36:3079-91
Siddiq, Mustafa M; Hannila, Sari S; Carmel, Jason B et al. (2015) Metallothionein-I/II Promotes Axonal Regeneration in the Central Nervous System. J Biol Chem 290:16343-56
Shivers, Kai-Yvonne; Nikolopoulou, Anastasia; Machlovi, Saima Ishaq et al. (2014) PACAP27 prevents Parkinson-like neuronal loss and motor deficits but not microglia activation induced by prostaglandin J2. Biochim Biophys Acta 1842:1707-19
Huang, Qian; Wang, Hu; Perry, Seth W et al. (2013) Negative regulation of 26S proteasome stability via calpain-mediated cleavage of Rpn10 subunit upon mitochondrial dysfunction in neurons. J Biol Chem 288:12161-74
Huang, He; Wang, Hu; Figueiredo-Pereira, Maria E (2013) Regulating the ubiquitin/proteasome pathway via cAMP-signaling: neuroprotective potential. Cell Biochem Biophys 67:55-66
Hannila, Sari S; Siddiq, Mustafa M; Carmel, Jason B et al. (2013) Secretory leukocyte protease inhibitor reverses inhibition by CNS myelin, promotes regeneration in the optic nerve, and suppresses expression of the transforming growth factor-? signaling protein Smad2. J Neurosci 33:5138-51
Myeku, Natura; Wang, Hu; Figueiredo-Pereira, Maria E (2012) cAMP stimulates the ubiquitin/proteasome pathway in rat spinal cord neurons. Neurosci Lett 527:126-31
Metcalfe, M J; Huang, Q; Figueiredo-Pereira, M E (2012) Coordination between proteasome impairment and caspase activation leading to TAU pathology: neuroprotection by cAMP. Cell Death Dis 3:e326
Myeku, Natura; Figueiredo-Pereira, Maria E (2011) Dynamics of the degradation of ubiquitinated proteins by proteasomes and autophagy: association with sequestosome 1/p62. J Biol Chem 286:22426-40

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