Abstract

The Center recognizes that the participating institutions and the wide variety of disciplines represented offers a uniquely fertile realm for training and education. The Administration &Management Core (AMC) will oversee the activities of the training core through a Education Training Committee (ETC) comprised of the Center I and the Pis of the individual research projects. In addition to the annual symposium as described in section 1.4, the Center will hold a second annual symposium specifically directed to provide the postdoctoral fellows and senior technicians the opportunity to present their work to their peers. The location for these symposia will rotate between the participating institutions to encourage the widest dissemination of information thereby encouraging cross-fertilization to the maximum extent possible. Two of these symposia will be incorporated by the USAMRICD's biennial Bioscience Review, a week-long international meeting focused exclusively on medical chemical defense research. This meeting is the premier international conference addressing all aspects of medical chemical defense and offers the ideal location for members of the Center to present their research findings, exchange ideas, and interact with the world leaders in this field.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54NS058183-07
Application #
8381729
Study Section
Special Emphasis Panel (ZRG1-MDCN-J)
Project Start
Project End
Budget Start
2012-09-01
Budget End
2013-08-31
Support Year
7
Fiscal Year
2012
Total Cost
$186,225
Indirect Cost

  Institution

Name
U.S. Army Medical Research Institute Chem Def
Department
Type
DUNS #
168812329
City
Aberdeen Proving Ground
State
MD
Country
United States
Zip Code
21010

  Publications

Ashani, Yacov; Leader, Haim; Aggarwal, Nidhi et al. (2016) In vitro evaluation of the catalytic activity of paraoxonases and phosphotriesterases predicts the enzyme circulatory levels required for in vivo protection against organophosphate intoxications. Chem Biol Interact 259:252-256
Smith, Carl D; Wright, Linnzi K M; Garcia, Gregory E et al. (2015) Hormone-dependence of sarin lethality in rats: Sex differences and stage of the estrous cycle. Toxicol Appl Pharmacol 287:253-7
Ben-David, Moshe; Sussman, Joel L; Maxwell, Christopher I et al. (2015) Catalytic stimulation by restrained active-site floppiness--the case of high density lipoprotein-bound serum paraoxonase-1. J Mol Biol 427:1359-1374
Magliery, Thomas J (2015) Protein stability: computation, sequence statistics, and new experimental methods. Curr Opin Struct Biol 33:161-8
Schneider, Jeannine D; Castilho, Alexandra; Neumann, Laura et al. (2014) Expression of human butyrylcholinesterase with an engineered glycosylation profile resembling the plasma-derived orthologue. Biotechnol J 9:501-10
Rockah-Shmuel, Liat; Tawfik, Dan S; Goldsmith, Moshe (2014) Generating targeted libraries by the combinatorial incorporation of synthetic oligonucleotides during gene shuffling (ISOR). Methods Mol Biol 1179:129-37
Dwyer, Mary; Javor, Sacha; Ryan, Daniel A et al. (2014) Novel human butyrylcholinesterase variants: toward organophosphonate detoxication. Biochemistry 53:4476-87
Ben-David, Moshe; Wieczorek, Grzegorz; Elias, Mikael et al. (2013) Catalytic metal ion rearrangements underline promiscuity and evolvability of a metalloenzyme. J Mol Biol 425:1028-38
Muralidharan, Mrinalini; Buss, Kristina; Larrimore, Katherine E et al. (2013) The Arabidopsis thaliana ortholog of a purported maize cholinesterase gene encodes a GDSL-lipase. Plant Mol Biol 81:565-76
Goldsmith, Moshe; Tawfik, Dan S (2013) Enzyme engineering by targeted libraries. Methods Enzymol 523:257-83

Showing the most recent 10 out of 48 publications