Exposure Core The function of the Exposure Core is to provide support in inhalation and other routes of exposures of sulfur mustard, therapeutic agents and other compounds of rodents to well-characterized test atmospheres that are required in the research plans of Project 1-5. The support will include (1) inhalation exposures of animals to SM vapor and aerosol/vapor mixtures, (2) animal dermal exposure to SM vapor, (3) animal ocular exposure to SM vapor, (4) inhalation exposure of therapeutic agents for efficacy, (5) in vitro exposure of tissues and blood to SM vapor, and (6) inhalation exposure to cigarette smoke for animal emphysema model. We have unique facilities and expertise to conduct these animal exposures with different routes of administration including inhalation, dermal, and ocular exposures to SM, inhalation exposures of therapeutical drugs and cigarette smoke, and in vitro exposure of tissues. We will provide services for (1) developing and performing inhalation exposures for animal studies, (2) ensuring high-quality exposure atmospheres (reproducible, stateof- the-art), (3) ensuring that the exposure generation system is operated and maintained according to predefined specifications, and (4) manipulating exposure atmospheres (e.g., adjusting concentration and size distribution of generated aerosols) for meeting the requirements specified for a given study. We have a permission to use and store chemical agents. We also have approved waste management and waste disposal practices for radioactive material. The Exposure Core is essential for the success of the proposed studies in this Center for Countermeasures Aagainst Chemical Threats.
| Mishra, Neerad C; Rir-sima-ah, Jules; Grotendorst, Gary R et al. (2012) Inhalation of sulfur mustard causes long-term T cell-dependent inflammation: possible role of Th17 cells in chronic lung pathology. Int Immunopharmacol 13:101-8 |
| Benson, Janet M; Tibbetts, Brad M; Weber, Waylon M et al. (2011) Uptake, tissue distribution, and excretion of 14C-sulfur mustard vapor following inhalation in F344 rats and cutaneous exposure in hairless guinea pigs. J Toxicol Environ Health A 74:875-85 |
| Benson, Janet M; Seagrave, JeanClare; Weber, Waylon M et al. (2011) Time course of lesion development in the hairless guinea-pig model of sulfur mustard-induced dermal injury. Wound Repair Regen 19:348-57 |
| Weber, Waylon M; Kracko, Dean A; Lehman, Mericka R et al. (2010) Inhalation exposure systems for the development of rodent models of sulfur mustard-induced pulmonary injury. Toxicol Mech Methods 20:14-24 |
| Chung, Pei-Yu; Lin, Tzung-Hua; Schultz, Gregory et al. (2010) Nanopyramid surface plasmon resonance sensors. Appl Phys Lett 96:261108 |
| Mishra, Neerad C; Rir-sima-ah, Jules; March, Thomas et al. (2010) Sulfur mustard induces immune sensitization in hairless guinea pigs. Int Immunopharmacol 10:193-9 |
| Cheng, Yung Sung; Bowen, Larry; Rando, Roy J et al. (2010) Exposing animals to oxidant gases: nose only vs. whole body. Proc Am Thorac Soc 7:264-8 |
| Seagrave, Jeanclare; Weber, Waylon M; Grotendorst, Gary R (2010) Sulfur mustard vapor effects on differentiated human lung cells. Inhal Toxicol 22:896-902 |
| Kang, Huaizhi; Liu, Haipeng; Phillips, Joseph A et al. (2009) Single-DNA molecule nanomotor regulated by photons. Nano Lett 9:2690-6 |
| Wang, Kemin; Tang, Zhiwen; Yang, Chaoyong James et al. (2009) Molecular engineering of DNA: molecular beacons. Angew Chem Int Ed Engl 48:856-70 |
Showing the most recent 10 out of 15 publications
