The overall mission of the Training and Education Core (TEC) will be to create the diverse human resources capable of conducting team-based interdisciplinary research focused on the complex problems posed by chemical threat agents. Advanced training in basic and translational toxicological sciences and drug discovery will be provided to the next generation of researchers, more specifically, technicians, medical and graduate students, postdoctoral fellows, and/or independent investigators within and outside the Center. Building upon the breadth of resources available at the UC Davis campus, the TEC will establish a special workshop and seminar series focused on chemical threat agent research. External instructors will be incorporated into the training and educational activities to provide cross-disciplinary depth. Trainees will have access to general and specialized coursework within the rich university curriculum and will be required to audit Drug Discovery and Development (PHA 207), a 3-unit graduate course offered by the UC Davis Pharmacology Department Interactions with other campus training programs, such as the NIEHS-funded Superfund Basic Research Program, the NIH Training Program in Biomolecular Technology at UC Davis, the UC System Life Sciences Informatics Program, and the UC Davis University Extension, will further enrich the educational activities available to trainees. The Center investigators bring to bear a critical mass of experience in multiple stages of drug discovery, development and toxicology, which are directly applicable to the overall goal of the proposed work. The TEC will facilitate hands-on interdisciplinary and collaborative research training in toxicology and drug discovery related to chemical threat agents in the laboratories of the project and core leaders. Resident members of the Center laboratories will receive training through a comlaination of individual mentorship, ongoing interdisciplinary research projects, conferences, and other training opportunities. Trainees will be motivated and challenged to work in flexible, task-oriented teams, which go beyond the boundaries of individual laboratories, to explore, understand and mitigate the health impacts of chemical threat agents. Trainees from CounterACT-associated laboratories across the country will be able to visit UC Davis laboratories for short periods of time and receive individualized, hands-on training in areas of their interest, and be able to participate in educational activities, including workshop and seminar series, and audit courses. By fulfilling these aims, the TEC will accomplish its goal of developing scientists with increased understanding of the concepts, challenges and opportunities in toxicology and drug discovery related to chemical threat agents. The core will serve the needs of both internal and visiting external trainees.

National Institute of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
Specialized Center--Cooperative Agreements (U54)
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Special Emphasis Panel (ZRG1-MDCN-J)
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University of California Davis
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Tu, Ranran; Armstrong, Jillian; Lee, Kin Sing Stephen et al. (2018) Soluble epoxide hydrolase inhibition decreases reperfusion injury after focal cerebral ischemia. Sci Rep 8:5279
Hampe, Alexander E; Li, Zidong; Sethi, Sunjay et al. (2018) A Microfluidic Platform to Study Astrocyte Adhesion on Nanoporous Gold Thin Films. Nanomaterials (Basel) 8:
Hobson, Brad A; Rowland, Douglas J; Supasai, Suangsuda et al. (2018) A magnetic resonance imaging study of early brain injury in a rat model of acute DFP intoxication. Neurotoxicology 66:170-178
Moeller, Benjamin; Espelien, Brenna; Weber, Waylon et al. (2018) The pharmacokinetics of ketamine following intramuscular injection to F344 rats. Drug Test Anal :
Pressly, Brandon; Nguyen, Hai M; Wulff, Heike (2018) GABAA receptor subtype selectivity of the proconvulsant rodenticide TETS. Arch Toxicol 92:833-844
Dhir, Ashish; Rogawski, Michael A (2018) Determination of minimal steady-state plasma level of diazepam causing seizure threshold elevation in rats. Epilepsia 59:935-944
Hobson, Brad A; Sisó, Sílvia; Rowland, Douglas J et al. (2017) From the Cover: MagneticResonance Imaging Reveals Progressive Brain Injury in Rats Acutely Intoxicated With Diisopropylfluorophosphate. Toxicol Sci 157:342-353
Brown, Brandon M; Shim, Heesung; Zhang, Miao et al. (2017) Structural Determinants for the Selectivity of the Positive KCa3.1 Gating Modulator 5-Methylnaphtho[2,1-d]oxazol-2-amine (SKA-121). Mol Pharmacol 92:469-480
Vasylieva, Natalia; Barnych, Bogdan; Rand, Amy et al. (2017) Sensitive Immunoassay for Detection and Quantification of the Neurotoxin, Tetramethylenedisulfotetramine. Anal Chem 89:5612-5619
Nguyen, Hai M; Singh, Vikrant; Pressly, Brandon et al. (2017) Structural Insights into the Atomistic Mechanisms of Action of Small Molecule Inhibitors Targeting the KCa3.1 Channel Pore. Mol Pharmacol 91:392-402

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