This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. I moved and started work with the University of Hawaii in August 2005. One of the major reasons for this move was to provide myself with the research support and the patient population with which to study heart function and disease during pregnancy. The prevalence of heart disease in Native Hawaiians is greater compared to other ethnic groups. Heart failure hits Native Hawaiians and Pacific Islanders five to ten years before it hits Caucasian and Asian groups. In addition, Hawaiians have an increased mortality rate from cardiovascular disease. Determination of heart function in all phases of pregnancy, delivery, and recovery can be critical to the care of the gravid cardiac patient. The physiologic demands of pregnancy can stress the heart function more than in the non-pregnant state. Therefore, better heart monitoring techniques are needed to help care for pregnant women with cardiomyopathy and other types of heart failure. Considering the increased work that the pregnant heart needs to do and the increase and early onset of heart disease in Hawaii, it is an ideal environment to pursue these clinical and research interests.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54RR014607-08
Application #
7380803
Study Section
Special Emphasis Panel (ZRR1-RI-1 (01))
Project Start
2006-08-01
Project End
2007-07-31
Budget Start
2006-08-01
Budget End
2007-07-31
Support Year
8
Fiscal Year
2006
Total Cost
$83,649
Indirect Cost
Name
University of Hawaii
Department
Obstetrics & Gynecology
Type
Schools of Medicine
DUNS #
965088057
City
Honolulu
State
HI
Country
United States
Zip Code
96822
Riangwiwat, Tanawan; Kohorn, Lindsay B; Chow, Dominic C et al. (2016) CD4/CD8 Ratio Predicts Peripheral Fat in HIV-Infected Population. J Acquir Immune Defic Syndr 72:e17-9
Wright, Tricia E; Schuetter, Renee; Tellei, Jacqueline et al. (2015) Methamphetamines and pregnancy outcomes. J Addict Med 9:111-7
Burlingame, J; Horiuchi, B; Ohana, P et al. (2012) The contribution of heart disease to pregnancy-related mortality according to the pregnancy mortality surveillance system. J Perinatol 32:163-9
Horton, J S; Yamamoto, S Y; Bryant-Greenwood, G D (2012) Relaxin augments the inflammatory IL6 response in the choriodecidua. Placenta 33:399-407
Hiraoka, Mark; Urschitz, Johann; Sultan, Omar et al. (2011) A polymorphism in the retinol binding protein 4 gene is not associated with gestational diabetes mellitus in several different ethnic groups. Hawaii Med J 70:164-7
Horton, J S; Yamamoto, S Y; Bryant-Greenwood, G D (2011) Relaxin modulates proinflammatory cytokine secretion from human decidual macrophages. Biol Reprod 85:788-97
Wright, T E; Milam, K A; Rougee, L et al. (2011) Agreement of umbilical cord drug and cotinine levels with maternal self-report of drug use and smoking during pregnancy. J Perinatol 31:324-9
Wright, Tricia E; Tam, Elizabeth (2010) Disparate rates of persistent smoking and drug use during pregnancy of women of Hawaiian ancestry. Ethn Dis 20:S1-215-8
Kendal-Wright, C E; Hubbard, D; Gowin-Brown, J et al. (2010) Stretch and inflammation-induced Pre-B cell colony-enhancing factor (PBEF/Visfatin) and Interleukin-8 in amniotic epithelial cells. Placenta 31:665-74
Urschitz, Johann; Kawasumi, Miyuri; Owens, Jesse et al. (2010) Helper-independent piggyBac plasmids for gene delivery approaches: strategies for avoiding potential genotoxic effects. Proc Natl Acad Sci U S A 107:8117-22

Showing the most recent 10 out of 59 publications