This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.Dr. Claire (Kendal) Wright's research focuses on a novel cytokine, Pre-B cell colony-enhancing factor (PBEF) also called Visfatin, and its role in the fetal membranes. She is also interested in the distension response of PBEF and how this interfaces with the cytokine cascade which develops at term to lead to timely parturition. She's been working on this cytokine in the human fetal membranes for the last two years under the mentorship of Dr Gillian Bryant-Greenwood (Professor of Molecular Endocrinology). Dr. Claire Kendal is currently a Junior Researcher in the Pacific Biosciences Research Center at UH where her aim is to become an independent researcher by obtaining independent NIH funding for her work. After obtaining her PhD in January 2001, she completed a short post-doctoral fellowship in collaboration with Glaxo Welcome at the Open University in the UK, she then completed three years as a post-doctoral fellow in the Department of Biochemistry at Imperial College London, UK. This was followed by her two years at the University of Hawai'i. Therefore, she has extensive experience in several different laboratories and has learned a wide range of research techniques. This has also allowed her to experience a broad range of biological research ranging from neuropathology, to growth factors and cell signaling, to her current situation, where she is expanding her expertise in the field of reproductive immunology.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54RR014607-10
Application #
7724702
Study Section
Special Emphasis Panel (ZRR1-RI-1 (01))
Project Start
2008-08-01
Project End
2009-07-31
Budget Start
2008-08-01
Budget End
2009-07-31
Support Year
10
Fiscal Year
2008
Total Cost
$137,477
Indirect Cost
Name
University of Hawaii
Department
Obstetrics & Gynecology
Type
Schools of Medicine
DUNS #
965088057
City
Honolulu
State
HI
Country
United States
Zip Code
96822
Riangwiwat, Tanawan; Kohorn, Lindsay B; Chow, Dominic C et al. (2016) CD4/CD8 Ratio Predicts Peripheral Fat in HIV-Infected Population. J Acquir Immune Defic Syndr 72:e17-9
Wright, Tricia E; Schuetter, Renee; Tellei, Jacqueline et al. (2015) Methamphetamines and pregnancy outcomes. J Addict Med 9:111-7
Horton, J S; Yamamoto, S Y; Bryant-Greenwood, G D (2012) Relaxin augments the inflammatory IL6 response in the choriodecidua. Placenta 33:399-407
Burlingame, J; Horiuchi, B; Ohana, P et al. (2012) The contribution of heart disease to pregnancy-related mortality according to the pregnancy mortality surveillance system. J Perinatol 32:163-9
Hiraoka, Mark; Urschitz, Johann; Sultan, Omar et al. (2011) A polymorphism in the retinol binding protein 4 gene is not associated with gestational diabetes mellitus in several different ethnic groups. Hawaii Med J 70:164-7
Horton, J S; Yamamoto, S Y; Bryant-Greenwood, G D (2011) Relaxin modulates proinflammatory cytokine secretion from human decidual macrophages. Biol Reprod 85:788-97
Wright, T E; Milam, K A; Rougee, L et al. (2011) Agreement of umbilical cord drug and cotinine levels with maternal self-report of drug use and smoking during pregnancy. J Perinatol 31:324-9
Kendal-Wright, C E; Hubbard, D; Gowin-Brown, J et al. (2010) Stretch and inflammation-induced Pre-B cell colony-enhancing factor (PBEF/Visfatin) and Interleukin-8 in amniotic epithelial cells. Placenta 31:665-74
Urschitz, Johann; Kawasumi, Miyuri; Owens, Jesse et al. (2010) Helper-independent piggyBac plasmids for gene delivery approaches: strategies for avoiding potential genotoxic effects. Proc Natl Acad Sci U S A 107:8117-22
Wright, Tricia E; Tam, Elizabeth (2010) Disparate rates of persistent smoking and drug use during pregnancy of women of Hawaiian ancestry. Ethn Dis 20:S1-215-8

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