Abstract

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This hypothesis will be tested through the following specific aims: 1. Assess the effect of standard-versus-aggressive RAAS inhibition on progression of atherosclerotic disease on a primary outcome of structural vascular changes as assessed by carotid intima media thickness, 2. Assess the effect of standard-versus-aggressive RAAS inhibition on progression of atherosclerotic disease on a secondary outcome of functional vascular changes as assessed by brachial artery reactivity, and 3. Examine the relationship of vascular changes to both baseline and change in urinary protein excretion rates.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54RR014616-08
Application #
7380860
Study Section
Special Emphasis Panel (ZRR1-RI-1 (01))
Project Start
2006-08-01
Project End
2007-07-31
Budget Start
2006-08-01
Budget End
2007-07-31
Support Year
8
Fiscal Year
2006
Total Cost
$200,733
Indirect Cost

  Institution

Name
Charles R. Drew University of Medicine & Science
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
785877408
City
Los Angeles
State
CA
Country
United States
Zip Code
90059

  Publications

Ren, Xiuhai; Lutfy, Kabirullah; Mangubat, Michael et al. (2013) Alterations in phosphorylated CREB expression in different brain regions following short- and long-term morphine exposure: relationship to food intake. J Obes 2013:764742
Tweed, Jesse Oliver; Hsia, Stanley H; Lutfy, Kabirullah et al. (2012) The endocrine effects of nicotine and cigarette smoke. Trends Endocrinol Metab 23:334-42
Hsia, Stanley H (2011) Insulin glargine compared to NPH among insulin-naïve, U.S. inner city, ethnic minority type 2 diabetic patients. Diabetes Res Clin Pract 91:293-9
Hsia, Stanley H; Navar, Maria D; Duran, Petra et al. (2011) Sitagliptin compared with thiazolidinediones as a third-line oral antihyperglycemic agent in type 2 diabetes mellitus. Endocr Pract 17:691-8
Calderón, José Luis; Bazargan, Mohsen; Sangasubana, Nisaratana et al. (2010) A comparison of two educational methods on immigrant Latinas breast cancer knowledge and screening behaviors. J Health Care Poor Underserved 21:76-90
Davidson, Mayer B; Schriger, David L (2010) Effect of age and race/ethnicity on HbA1c levels in people without known diabetes mellitus: implications for the diagnosis of diabetes. Diabetes Res Clin Pract 87:415-21
Jones, Loretta; Lu, Michael C; Lucas-Wright, Aziza et al. (2010) One Hundred Intentional Acts of Kindness toward a Pregnant Woman: building reproductive social capital in Los Angeles. Ethn Dis 20:S2-36-40
Kilimnik, German; Kim, Abraham; Steiner, Donald F et al. (2010) Intraislet production of GLP-1 by activation of prohormone convertase 1/3 in pancreatic ?-cells in mouse models of ß-cell regeneration. Islets 2:149-55
Anghel, A; Jamieson, C A M; Ren, X et al. (2010) Gene expression profiling following short-term and long-term morphine exposure in mice uncovers genes involved in food intake. Neuroscience 167:554-66
Chen, John; Patel, Roshni; Friedman, Theodore C et al. (2010) The Behavioral and Pharmacological Actions of NMDA Receptor Antagonism are Conserved in Zebrafish Larvae. Int J Comp Psychol 23:82-90

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