This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The human immunodeficiency virus (HIV) is transmitted to over 16,000 people each day worldwide. Our ongoing studies indicate P. gingivalis can inhibit HIV entry. The purpose of this study is to elucidate the mechanism by which the P. gingivalis component blocks the course of HIV infection. The specific effort of this proposal is to purify and characterize the inhibitory component of P. gingivalis, which may be capable of interfering with the oral transmission of HIV. Our initial investigation is aimed at determination of the prevalence and the anti-HIV activity of P. gingivalis strains isolated from periodontitis sites in HIV seropositive and HIV seronegative individuals, examination of correlation of viral loads and 17-kDa anti-HIV protein, and investigation of the effect of co-infection of HIV-1 and P. gingivalis on the pathogenicities of the organisms. The knowledge gained from this study is expected to increase our understanding of the rarity of HIV oral transmission and to provide new insights into the viral entry process. Furthermore, the study of the P. gingivalis inhibitory component might lead to the discovery of an additional target to complement current anti-HIV drugs.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54RR019192-04
Application #
7380795
Study Section
Special Emphasis Panel (ZRR1-RCMI-2 (01))
Project Start
2006-09-01
Project End
2007-08-31
Budget Start
2006-09-01
Budget End
2007-08-31
Support Year
4
Fiscal Year
2006
Total Cost
$350,916
Indirect Cost
Name
Meharry Medical College
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
041438185
City
Nashville
State
TN
Country
United States
Zip Code
37208
Sanderson, Maureen; O'Hara, Heather; Foderingham, Nia et al. (2015) Type 2 diabetes and mammographic breast density among underserved women. Cancer Causes Control 26:303-309
Wang, Ziqing; Luo, Yi; Shao, Qiujia et al. (2014) Heat-stable molecule derived from Streptococcus cristatus induces APOBEC3 expression and inhibits HIV-1 replication. PLoS One 9:e106078
Timmons, Christine L; Shao, Qiujia; Wang, Chenliang et al. (2013) GB virus type C E2 protein inhibits human immunodeficiency virus type 1 assembly through interference with HIV-1 gag plasma membrane targeting. J Infect Dis 207:1171-80
Zamani, Christopher; Elzey, Jared D; Hildreth, James Ek (2013) Greater ethnic diversity correlates with lower HIV prevalence in Africa: justification for an alloimmunity vaccine. HIV AIDS (Auckl) 5:75-80
Marrs, Christy N; Knobel, Susan M; Zhu, Wen Qin et al. (2012) Evidence for Gardnerella vaginalis uptake and internalization by squamous vaginal epithelial cells: implications for the pathogenesis of bacterial vaginosis. Microbes Infect 14:500-8
Emeagwali, Nkiruka; Hildreth, James E K (2012) Human immunodeficiency virus type 1 Vpu and cellular TASK proteins suppress transcription of unintegrated HIV-1 DNA. Virol J 9:277
Liu, Ling; Sutton, Jessica; Woodruff, Elvin et al. (2012) Defective HIV-1 particle assembly in AP-3-deficient cells derived from patients with Hermansky-Pudlak syndrome type 2. J Virol 86:11242-53
Cooper, JoAnn; Liu, Ling; Woodruff, Elvin A et al. (2011) Filamin A protein interacts with human immunodeficiency virus type 1 Gag protein and contributes to productive particle assembly. J Biol Chem 286:28498-510
Taylor, Harry E; Linde, Michael E; Khatua, Atanu K et al. (2011) Sterol regulatory element-binding protein 2 couples HIV-1 transcription to cholesterol homeostasis and T cell activation. J Virol 85:7699-709
Alcendor, Donald J; Knobel, Susan; Desai, Prashant et al. (2011) KSHV regulation of fibulin-2 in Kaposi's sarcoma: implications for tumorigenesis. Am J Pathol 179:1443-54

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