The long-range goal of this application is to augment and strengthen the HIV/AIDS research capabilities of faculty and trainees at Meharry Medical College. The Meharry Center for Health Disparities Research in HIV (MCHDR) will create a research environment in which faculty and trainees will enhance their research skills, conduct high quality research, disseminate their research in peer-reviewed publications, and compete with greater success for independent extramural research funds. The programs proposed in this application will assist the institution in its mission to conduct research with a special emphasis on health disparities: diseases and conditions that disproportionately affect ethnic minority populations.
The specific aims of the current application are: Phase I: 1) To recruit and employ an established, nationally recognized clinical scientist to serve as a focus to attract and develop other research faculty and to lead the Comprehensive Center for Disparities Research in HIV/AIDS at Meharry Medical College. 2) To enhance the scholarly environment for research in HIV/AIDS to ensure that the three subproject investigators in this application become fully independent scientists 3) To establish a sound administrative and scientific infrastructure for the growth of the center. 4) To renovate a physical site at Meharry Medical College for the Comprehensive Center for Disparities Research in HIV/AIDS. Phase II: 5) To recruit and employ three established investigators who study HIV or closely related subjects. 6) To increase the number of mainstream research project grants that fund HIV research at Meharry.7) To increase the number of Meharry Faculty with collaborative, extramural funding for research in HIV and AIDS. 8) To obtain funding for mainstream program project and institutional NRSA grants in HIV.9) To increase the number of peer-reviewed publications by HIV/AIDS investigators. The Meharry MCHDR is a consortium project involving Vanderbilt University and the University of Wisconsin-Milwaukee. The proposed program consists of an administrative core and three collaborative research subprojects. The core provides administrative support for HIV/AIDS faculty with an emphasis on the collaborative projects. The core also includes a number of faculty recruitment and development activities including workhops on grant-writing and publication, workshops an HIV/AIDS seminar program and an annual regional HIV/AIDS symposium.
|Sanderson, Maureen; O'Hara, Heather; Foderingham, Nia et al. (2015) Type 2 diabetes and mammographic breast density among underserved women. Cancer Causes Control 26:303-309|
|Wang, Ziqing; Luo, Yi; Shao, Qiujia et al. (2014) Heat-stable molecule derived from Streptococcus cristatus induces APOBEC3 expression and inhibits HIV-1 replication. PLoS One 9:e106078|
|Timmons, Christine L; Shao, Qiujia; Wang, Chenliang et al. (2013) GB virus type C E2 protein inhibits human immunodeficiency virus type 1 assembly through interference with HIV-1 gag plasma membrane targeting. J Infect Dis 207:1171-80|
|Zamani, Christopher; Elzey, Jared D; Hildreth, James Ek (2013) Greater ethnic diversity correlates with lower HIV prevalence in Africa: justification for an alloimmunity vaccine. HIV AIDS (Auckl) 5:75-80|
|Marrs, Christy N; Knobel, Susan M; Zhu, Wen Qin et al. (2012) Evidence for Gardnerella vaginalis uptake and internalization by squamous vaginal epithelial cells: implications for the pathogenesis of bacterial vaginosis. Microbes Infect 14:500-8|
|Emeagwali, Nkiruka; Hildreth, James E K (2012) Human immunodeficiency virus type 1 Vpu and cellular TASK proteins suppress transcription of unintegrated HIV-1 DNA. Virol J 9:277|
|Liu, Ling; Sutton, Jessica; Woodruff, Elvin et al. (2012) Defective HIV-1 particle assembly in AP-3-deficient cells derived from patients with Hermansky-Pudlak syndrome type 2. J Virol 86:11242-53|
|Cooper, JoAnn; Liu, Ling; Woodruff, Elvin A et al. (2011) Filamin A protein interacts with human immunodeficiency virus type 1 Gag protein and contributes to productive particle assembly. J Biol Chem 286:28498-510|
|Taylor, Harry E; Linde, Michael E; Khatua, Atanu K et al. (2011) Sterol regulatory element-binding protein 2 couples HIV-1 transcription to cholesterol homeostasis and T cell activation. J Virol 85:7699-709|
|Alcendor, Donald J; Knobel, Susan; Desai, Prashant et al. (2011) KSHV regulation of fibulin-2 in Kaposi's sarcoma: implications for tumorigenesis. Am J Pathol 179:1443-54|
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