This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Technical Research Project 4, The Proteolysis Map (PMAP), will apply computational methods to develop an all-encompassing computational map of proteolytic networks. The Proteolysis Map will aid scientists in reasoning through the data sets by allowing one to computationally interrogate the effects of biological stimuli, drug inhibition, or pathophysiologic perturbations on proteolytic pathways. The Proteolysis Map will be created through an iterative learning-based approach, populated with information on i) the three dimensional structure of proteases, ii) their substrate specificity ii) results of degradomic experiments in whole proteomes, iv) all potential co-expression and/or co-localization patterns reported from gene expression profiling and from other proteomic studies.
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