This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Driving Biological Project 4: Protease Pathways Localized in Endothelial Cell Caveolae Proteases are frequently synthesized as inactive zymogens, and are then activated by another proteases, as part of a cascade. These cascades of proteolysis are frequently facilitated by compartmentalization. Over the last decade the role of plasma membrane microdomains, called caveolae, in regulating cell signaling has become increasingly apparent. We will test the hypothesis that caveolae have another role, the compartmentalization of interacting proteases

National Institute of Health (NIH)
National Center for Research Resources (NCRR)
Specialized Center--Cooperative Agreements (U54)
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Special Emphasis Panel (ZRG1-BST-D (55))
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Sanford-Burnham Medical Research Institute
La Jolla
United States
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Savinov, Alexei Y; Strongin, Alex Y (2013) Targeting the T-cell membrane type-1 matrix metalloproteinase-CD44 axis in a transferred type 1 diabetes model in NOD mice. Exp Ther Med 5:438-442
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