This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Core 2 develops tools to facilitate and extend the research efforts made by investigators in computational biology and biomedical computing, including those involved in Core 3 (as shown in Figure 2-1). We have classified these tools into three categories: 1. Data Analysis: mathematical and computational methods that solve specific problems faced by biomedical investigators. 2. User Interaction: methods by which investigators can interact with both data and algorithms. 3. Knowledge Management: management of information about investigators, projects, programs, and data. This includes automated methods for data access control, file format translation, data provenance, tracking and program execution requirements.Each tool is of interest in its own right, and each tool is revisited in each of four major subsections: A.
Specific Aims B. Background and Significance C. Preliminary Studies D. Design and Methods. Before describing the tools themselves, it is pertinent to introduce the larger framework into which these tools are integrated. We refer to this framework as a computational atlas.

National Institute of Health (NIH)
National Center for Research Resources (NCRR)
Specialized Center--Cooperative Agreements (U54)
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Special Emphasis Panel (ZRG1-BST-C (55))
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University of California Los Angeles
Schools of Medicine
Los Angeles
United States
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