This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. A.
Specific Aims The objective of this component of our MeTRC Program is to establish a Proteomics Core facility, which will serve the broad research community and will significantly enhance translational and clinical research at Meharry Medical College. The goals include acquiring an LC-MS / MS system for mass spectrometry analysis of protein samples, and to establish the appropriate infrastructure for proteomics education and outreach among our faculty and trainees. This activity is aimed to provide researchers and trainees the ability to obtain critical information about their proteins of interest and to advance protein discovery in basic, clinical and translational settings.
The specific aims of the proposed activity are: (1) To develop a Proteomics Core Facility to support Meharry's clinical and translational research activities;and (2) To develop collaborations and partnerships inside and outside of Meharry Medical College that accelerate clinical and translational research, with the common link being the reliance on state-of-the-art proteomics strategies.
| Dash, Sabyasachi; Balasubramaniam, Muthukumar; Dash, Chandravanu et al. (2018) Biotin-based Pulldown Assay to Validate mRNA Targets of Cellular miRNAs. J Vis Exp : |
| Dong, Xin-Hong; Ho, Meng-Hsuan; Liu, Bindong et al. (2018) Role of Porphyromonas gingivalis outer membrane vesicles in oral mucosal transmission of HIV. Sci Rep 8:8812 |
| Balasubramaniam, Muthukumar; Pandhare, Jui; Dash, Chandravanu (2018) Are microRNAs Important Players in HIV-1 Infection? An Update. Viruses 10: |
| Welch, Jennifer L; Madison, Marisa N; Margolick, Joseph B et al. (2017) Effect of prolonged freezing of semen on exosome recovery and biologic activity. Sci Rep 7:45034 |
| Morris, Matthew C; Kouros, Chrystyna D; Janecek, Kim et al. (2017) Community-level moderators of a school-based childhood sexual assault prevention program. Child Abuse Negl 63:295-306 |
| Weems, Ebony; Singha, Ujjal K; Smith, Joseph T et al. (2017) The divergent N-terminal domain of Tim17 is critical for its assembly in the TIM complex in Trypanosoma brucei. Mol Biochem Parasitol 218:4-15 |
| Dash, Sabyasachi; Balasubramaniam, Muthukumar; Rana, Tanu et al. (2017) Poly (ADP-Ribose) Polymerase-1 (PARP-1) Induction by Cocaine Is Post-Transcriptionally Regulated by miR-125b. eNeuro 4: |
| Balasubramaniam, Muthukumar; Davids, Benem; Addai, Amma B et al. (2017) Measurement of In Vitro Integration Activity of HIV-1 Preintegration Complexes. J Vis Exp : |
| Pulliam, Stephanie R; Uzhachenko, Roman V; Adunyah, Samuel E et al. (2016) Common gamma chain cytokines in combinatorial immune strategies against cancer. Immunol Lett 169:61-72 |
| Kaneshiro, Bliss; Edelman, Alison; Dash, Chandravanu et al. (2016) Effect of oral contraceptives and doxycycline on endometrial MMP-2 and MMP-9 activity. Contraception 93:65-9 |
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