This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.The Vanderbilt Institute for Clinical and Translational Research (VICTR) is being formed in response to this ISA initiative and aims to address a multitude of challenges which are slowing the pace, efficiency, and success of clinical and translational research and which ultimately created immense lost opportunities to develop therapies for important human diseases. Recognizing these barriers, Vanderbilt began taking specific remedial actions almost 5 years ago. Under this CTSA, VICTR will be organized and designed to :ocus on both bench to bedside and bedside to practice translation. Importantly, we have formed a focused partnership with Meharry Medical College leveraging a strong Meharry-Vanderbilt Alliance. We will reengineer processes to remove impediments and release investigators from administrative burdens through the creation and/or optimization of institutional infrastructure, including, shared translational technologies, centralized record keeping, and one-stop shopping for support. We will produce inspired personnel who are trained in the bi-directional process of translational research via a multi-faceted education, training program that is linked directly to incentives and career development pathways as well as ongoing development. We will support translational research with resources, methodological development activities, and expert support staff with participant and clinical interactions resources, resources for translating clinical discoveries into practice, including community engagement, knowledge management and biomedical informatics, and study design, biostatistics and clinical research ethics. We will foster innovation by stimulating contribution from collaborators, creating value-added review processes, and implementing long-range planning which includes active solicitation of pilot research. We will enrich the translational research environment with informatics based tools that enhance hypothesis generation, planning, innovation, evaluation and program management by developing a web-based interactive work flow, decision support tool and database which allows us to manage VICTR workflow processes to optimize data capture in the course of conducting daily activities. These innovations will be evaluated to determine their effect on stated CTSA objectives. Our long term vision, together with the CTSA consortium, is to measurably improve population health.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Linked Specialized Center Cooperative Agreement (UL1)
Project #
5UL1RR024975-02
Application #
7719812
Study Section
Special Emphasis Panel (ZRR1-CR-1 (01))
Project Start
2008-06-01
Project End
2009-05-31
Budget Start
2008-06-01
Budget End
2009-05-31
Support Year
2
Fiscal Year
2008
Total Cost
$312,544
Indirect Cost
Name
Vanderbilt University Medical Center
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
004413456
City
Nashville
State
TN
Country
United States
Zip Code
37212
Huo, Yuankai; Xu, Zhoubing; Bao, Shunxing et al. (2018) Splenomegaly Segmentation using Global Convolutional Kernels and Conditional Generative Adversarial Networks. Proc SPIE Int Soc Opt Eng 10574:
Balasubramaniam, Muthukumar; Pandhare, Jui; Dash, Chandravanu (2018) Are microRNAs Important Players in HIV-1 Infection? An Update. Viruses 10:
Garber, J; Weersing, V R; Hollon, S D et al. (2018) Prevention of Depression in At-Risk Adolescents: Moderators of Long-term Response. Prev Sci 19:6-15
Bobo, Meg F; Bao, Shunxing; Huo, Yuankai et al. (2018) Fully Convolutional Neural Networks Improve Abdominal Organ Segmentation. Proc SPIE Int Soc Opt Eng 10574:
Hartman, Lauren; Zhu, Yuwei; Edwards, Kathryn M et al. (2018) Underdiagnosis of Influenza Virus Infection in Hospitalized Older Adults. J Am Geriatr Soc 66:467-472
Restrepo, Nicole A; Laper, Sarah M; Farber-Eger, Eric et al. (2018) Local genetic ancestry in CDKN2B-AS1 is associated with primary open-angle glaucoma in an African American cohort extracted from de-identified electronic health records. BMC Med Genomics 11:70
Flyak, Andrew I; Kuzmina, Natalia; Murin, Charles D et al. (2018) Broadly neutralizing antibodies from human survivors target a conserved site in the Ebola virus glycoprotein HR2-MPER region. Nat Microbiol 3:670-677
Farmer, Diana L; Thom, Elizabeth A; Brock 3rd, John W et al. (2018) The Management of Myelomeningocele Study: full cohort 30-month pediatric outcomes. Am J Obstet Gynecol 218:256.e1-256.e13
Bernardo-Colón, Alexandra; Vest, Victoria; Clark, Adrienne et al. (2018) Antioxidants prevent inflammation and preserve the optic projection and visual function in experimental neurotrauma. Cell Death Dis 9:1097
Kaoutzanis, Christodoulos; Ganesh Kumar, Nishant; O'Neill, Dillon et al. (2018) Enhanced Recovery Pathway in Microvascular Autologous Tissue-Based Breast Reconstruction: Should It Become the Standard of Care? Plast Reconstr Surg 141:841-851

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