This CTSA application from Washington University in St. Louis (WU) is built on a long institutional history of outstanding biomedical research, research training, and patient care.WU is the recipient of the 4 clinical research and training grants that form the basis of the CTSA (GCRC, currently in its 46th year of funding, and K12, K30, and T32 grants.) Another critical element is WU's new BioMed 21 strategic initiative in multidisciplinary, collaborative research in genome sciences, biological imaging, and clinical investigation. All these elements will be conjoined with other existing resources at WU to form a transformational new Institute of Clinical and Translational Sciences (ICTS). By implementing the 15 key Program Functions described in this application, the ICTS will conceptually and operationally reinvent and reinvigorate clinical and translational research and clinical research training at WU. An unprecedented level of partnership with other academic, healthcare, community and scientific institutions that complement our core expertise in laboratory and clinical research and research training is central to the transformationthat will be led by the ICTS. Our partners include BJC HealthCare, an integrated academicand community health care delivery system;Saint Louis University School of Public Health, Graduate School and Doisy College of Health Sciences;University of Missouri St. Louis College of Nursing;Southern Illinois University EdwardsvilleSchool of Nursing;and St. Louis College of Pharmacy;key organizations promoting community health as well as biomedical and pharmaceutical companies in the St. Louis area. The coupling of these resources creates an outstanding environment to make basic laboratory discoveries that can then be translated into clinical research protocolsand ultimately into advances in clinical practice and patient care through extensive community interactions and commercial partnerships."""""""" To ensure the success of the ICTS, WU has made substantial commitments of space and financial support. Barnes-Jewishand St. Louis Children!s?lospitals, our academic hospital-partnersrand-BdC HealthCare, our affiliated health system, have also made substantial commitments to the clinical research activities of the ICTS. These additional resources coupled with the existing high quality programs in clinical and translational science ensure that WU will make outstanding contributions to this NIH initiative.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Linked Specialized Center Cooperative Agreement (UL1)
Project #
5UL1RR024992-05
Application #
8097986
Study Section
Special Emphasis Panel (ZRR1-CR-1 (02))
Program Officer
Sawczuk, Andrea
Project Start
2007-09-17
Project End
2012-06-26
Budget Start
2011-06-01
Budget End
2012-06-26
Support Year
5
Fiscal Year
2011
Total Cost
$8,453,813
Indirect Cost
Name
Washington University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
068552207
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
Tuttle, Lori J; Bittel, Daniel C; Bittel, Adam J et al. (2018) Early-Onset Physical Frailty in Adults With Diabesity and Peripheral Neuropathy. Can J Diabetes 42:478-483
Savage, Jeanne E; Salvatore, Jessica E; Aliev, Fazil et al. (2018) Polygenic Risk Score Prediction of Alcohol Dependence Symptoms Across Population-Based and Clinically Ascertained Samples. Alcohol Clin Exp Res 42:520-530
Kriska, Andrea; El Ghormli, Laure; Copeland, Kenneth C et al. (2018) Impact of lifestyle behavior change on glycemic control in youth with type 2 diabetes. Pediatr Diabetes 19:36-44
Matsunuma, Ryoichi; Chan, Doug W; Kim, Beom-Jun et al. (2018) DPYSL3 modulates mitosis, migration, and epithelial-to-mesenchymal transition in claudin-low breast cancer. Proc Natl Acad Sci U S A 115:E11978-E11987
Lin, Huawen; Cliften, Paul F; Dutcher, Susan K (2018) MAPINS, a Highly Efficient Detection Method That Identifies Insertional Mutations and Complex DNA Rearrangements. Plant Physiol 178:1436-1447
TreviƱo-Villarreal, J Humberto; Reynolds, Justin S; Bartelt, Alexander et al. (2018) Dietary protein restriction reduces circulating VLDL triglyceride levels via CREBH-APOA5-dependent and -independent mechanisms. JCI Insight 3:
Zhong, Diana; Liang, Stephen Y (2018) Approach to Transplant Infectious Diseases in the Emergency Department. Emerg Med Clin North Am 36:811-822
Rodebaugh, Thomas L; Tonge, Natasha A; Piccirillo, Marilyn L et al. (2018) Does centrality in a cross-sectional network suggest intervention targets for social anxiety disorder? J Consult Clin Psychol 86:831-844
Bumpus, Emily; Hershey, Tamara; Doty, Tasha et al. (2018) Understanding activity participation among individuals with Wolfram Syndrome. Br J Occup Ther 81:348-357
Hoekel, James; Narayanan, Anagha; Rutlin, Jerrel et al. (2018) Visual pathway function and structure in Wolfram syndrome: patient age, variation and progression. BMJ Open Ophthalmol 3:e000081

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