The purpose of this application is to enhance both the process and benefits of clinical andtranslational research by bringing together the diverse resources of the Johns Hopkins Medical Institutions (JHMI) and creating a new model for carrying out scientific research. This model will create a new paradigm for conducting multidisciplinary research by addressing critical barriers that currently impede the progress of basic science discoveries to the clinic. Johns Hopkins currently has two General Clinical Research Centers, two K-12 awards, one K-30 award, and one T-32 award providing substantial experience in conducting translational research and in training, education and career development of clinical and translational researchers. We propose to create a new Johns Hopkins Institute for Clinical and Translational Research whose goal is to coordinate, synergize and transform clinical and translational research within Johns Hopkins. The new Johns Hopkins Institute for Clinical and Translational Research will benefit from a broad vision supplied by an expansive external advisory board and an influential internal advisory board. The Institute will synergize many existing translational research efforts across the Johns Hopkins Schools of Engineering, Medicine, Nursing and Public Health. Research training, education and career development will be transformed to reach more learners with more tailored products. Clinical and translational researchers will be supported by new programs in biostatistics, innovative methodology, patient recruitment, navigating through regulatory offices, clinical research management systems, data safety and monitoring programs, building community bridges, research ethics consultations, and the Accelerated Translational Incubator Program (pilot program). New translational cores in drug, device and vaccine development, proteomics, genetics and imaging will create new translational research teams. We fully expect that the new Institute and the association with other CTSA medical institutions will transform how translational research is conducted at Johns Hopkins.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Linked Specialized Center Cooperative Agreement (UL1)
Project #
3UL1RR025005-03S3
Application #
7881902
Study Section
Special Emphasis Panel (ZRR1-CR-1 (02))
Program Officer
Sachs, Jody
Project Start
2009-09-15
Project End
2011-09-14
Budget Start
2009-09-15
Budget End
2011-09-14
Support Year
3
Fiscal Year
2009
Total Cost
$533,053
Indirect Cost
Name
Johns Hopkins University
Department
Pediatrics
Type
Schools of Medicine
DUNS #
001910777
City
Baltimore
State
MD
Country
United States
Zip Code
21218
El Khoudary, Samar R; Ceponiene, Indre; Samargandy, Saad et al. (2018) HDL (High-Density Lipoprotein) Metrics and Atherosclerotic Risk in Women. Arterioscler Thromb Vasc Biol 38:2236-2244
Tibuakuu, Martin; Zhao, Di; Saxena, Ankita et al. (2018) Low thigh muscle mass is associated with coronary artery stenosis among HIV-infected and HIV-uninfected men: The Multicenter AIDS Cohort Study (MACS). J Cardiovasc Comput Tomogr 12:131-138
Oelsner, Elizabeth C; Smith, Benjamin M; Hoffman, Eric A et al. (2018) Associations between emphysema-like lung on CT and incident airflow limitation: a general population-based cohort study. Thorax 73:486-488
Dellibovi-Ragheb, Teegan A; Jhun, Hugo; Goodman, Christopher D et al. (2018) Host biotin is required for liver stage development in malaria parasites. Proc Natl Acad Sci U S A 115:E2604-E2613
Hannawi, Y; Yanek, L R; Kral, B G et al. (2018) Hypertension Is Associated with White Matter Disruption in Apparently Healthy Middle-Aged Individuals. AJNR Am J Neuroradiol 39:2243-2248
Kubota, Yasuhiko; Alonso, Alvaro; Heckbert, Susan R et al. (2018) Homocysteine and Incident Atrial Fibrillation: The Atherosclerosis Risk in Communities Study and the Multi-Ethnic Study of Atherosclerosis. Heart Lung Circ :
Kwon, Younghoon; Jacobs Jr, David R; Lutsey, Pamela L et al. (2018) ""Sleep disordered breathing and ECG R-wave to radial artery pulse delay, The Multi-Ethnic Study of Atherosclerosis"". Sleep Med 48:172-179
Irvin, Marguerite R; Sitlani, Colleen M; Noordam, Raymond et al. (2018) Genome-wide meta-analysis of SNP-by9-ACEI/ARB and SNP-by-thiazide diuretic and effect on serum potassium in cohorts of European and African ancestry. Pharmacogenomics J :
Rhee, Rennie L; Davis, John C; Ding, Linna et al. (2018) The Utility of Urinalysis in Determining the Risk of Renal Relapse in ANCA-Associated Vasculitis. Clin J Am Soc Nephrol 13:251-257
Floyd, J S; Sitlani, C M; Avery, C L et al. (2018) Large-scale pharmacogenomic study of sulfonylureas and the QT, JT and QRS intervals: CHARGE Pharmacogenomics Working Group. Pharmacogenomics J 18:127-135

Showing the most recent 10 out of 1181 publications