This subproject represents an estimate of the percentage of the CTSA funding that is being utilized for a broad area of research (AIDS research, pediatric research, or clinical trials). The Total Cost listed is only an estimate of the amount of CTSA infrastructure going towards this area of research, not direct funding provided by the NCRR grant to the subproject or subproject staff. The University of Arkansas for Medical Sciences (UAMS) is undertaking a series of initiatives aimed at synergizing existing clinical and translational research programs, and revamping the institutional research endeavor. The Arkansas Center for Clinical and Translational Research (CCTR) has been formed which unites all UAMS Colleges and its Graduate School behind the translational research endeavor. Our overarching goal is to establish an integrative CCTR that transforms the pace, effectiveness, and quality of translational research at UAMS, resulting in better health for all Arkansans. The 4 overall goals are as follows:
Specific Aim 1 : Educate the next generation of physicians and scientists in collaborative translational science;
Specific Aim 2 : Develop partnerships with Arkansas's communities to assure that our research addresses their concerns and needs, and that they benefit from our findings;
Specific Aim 3 : Champion nnovation and collaboration in research and discovery to bring new technologies to Arkansans;
Specific Aim 4 : Provide administrative structure that facilitates translational research through promoting productive interactions among basic science, clinical, health services, and health policy researchers. These goals are supported by intensive component programs (Governance, Regulatory Support, Participant and Clinical Interaction Resources, Informatics, Design/Biostatistics, Ethics, Education, Novel methodologies/Pilot studies, Translational Technologies, Community Engagement) plus 3 additional program components in which we are particularly strong, and which will serve well the greater Arkansas community: These are Health Services Research, Behavioral Research, and Epidemiology. Arkansas has an outstanding telemedicine program to support our community-based research efforts. UAMS is developing a new Division of Informatics. Thus, the Arkansas CCTR will bring considerable added value to Arkansas, and represent a model program for research that extends nationally to rural communities. The CCTR will foster the formation of a cross-disciplinary, multi-faceted interface among the laboratory bench, patient bedside, and wider community through an interactive network of scientists. It will also facilitate training of future clinical and translational investigators across the health sciences and forge strategic collaborations among researchers, community clinicians, clinical research networks, professional societies, industry, and policy makers to facilitate the development of innovative research, increase the responsiveness and efficiency of translational research, and catalyze the application of new knowledge and techniques to clinical practice at the front lines of patient care.

Public Health Relevance

The Arkansas CCTR along with this CTSA interface will facilitate training of future clinical and translational investigators across the health sciences and forge strategic collaborations among researchers, community clinicians, clinical research networks, professional societies, industry, and policy makers to facilitate development of innovative research, increase the responsiveness and efficiency of translational research, and catalyze the application of new knowledge and techniques to clinical practice at the front lines of patient care.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Linked Specialized Center Cooperative Agreement (UL1)
Project #
5UL1RR029884-03
Application #
8365162
Study Section
Special Emphasis Panel (ZRR1-CR-1 (01))
Project Start
2011-04-01
Project End
2012-03-31
Budget Start
2011-04-01
Budget End
2012-03-31
Support Year
3
Fiscal Year
2011
Total Cost
$570,329
Indirect Cost
Name
University of Arkansas for Medical Sciences
Department
Obstetrics & Gynecology
Type
Schools of Medicine
DUNS #
122452563
City
Little Rock
State
AR
Country
United States
Zip Code
72205
Padala, Prasad R; Padala, Kalpana P; Lensing, Shelly Y et al. (2018) Repetitive transcranial magnetic stimulation for apathy in mild cognitive impairment: A double-blind, randomized, sham-controlled, cross-over pilot study. Psychiatry Res 261:312-318
Gannon, Brenda M; Williamson, Adrian; Rice, Kenner C et al. (2018) Role of monoaminergic systems and ambient temperature in bath salts constituent 3,4-methylenedioxypyrovalerone (MDPV)-elicited hyperthermia and locomotor stimulation in mice. Neuropharmacology 134:13-21
Nowak, Grazyna; Bakajsova-Takacsova, Diana (2018) Protein kinase C? targets respiratory chain and mitochondrial membrane potential but not F0 F1 -ATPase in renal cells injured by oxidant. J Cell Biochem 119:9394-9407
Zielinski, Melissa J; Privratsky, Anthony A; Smitherman, Sonet et al. (2018) Does development moderate the effect of early life assaultive violence on resting-state networks? An exploratory study. Psychiatry Res Neuroimaging 281:69-77
Xiong, Jinhu; Almeida, Maria; O'Brien, Charles A (2018) The YAP/TAZ transcriptional co-activators have opposing effects at different stages of osteoblast differentiation. Bone 112:1-9
Engelen, Mariƫlle P K J; Klimberg, V Suzanne; Allasia, Arianna et al. (2018) Major surgery diminishes systemic arginine availability and suppresses nitric oxide response to feeding in patients with early stage breast cancer. Clin Nutr 37:1645-1653
Piemontese, Marilina; Almeida, Maria; Robling, Alexander G et al. (2017) Old age causes de novo intracortical bone remodeling and porosity in mice. JCI Insight 2:
Ruebel, Meghan L; Cotter, Matthew; Sims, Clark R et al. (2017) Obesity Modulates Inflammation and Lipid Metabolism Oocyte Gene Expression: A Single-Cell Transcriptome Perspective. J Clin Endocrinol Metab 102:2029-2038
Shewale, Anand R; Barnes, Charles L; Fischbach, Lori A et al. (2017) Comparison of Low-, Moderate-, and High-Molecular-Weight Hyaluronic Acid Injections in Delaying Time to Knee Surgery. J Arthroplasty 32:2952-2957.e21
Jonker, Renate; Deutz, Nicolaas Ep; Erbland, Marcia L et al. (2017) Effectiveness of essential amino acid supplementation in stimulating whole body net protein anabolism is comparable between COPD patients and healthy older adults. Metabolism 69:120-129

Showing the most recent 10 out of 292 publications