This revised application for a Clinical and Translational Science Award (CTSA) would support the continueddevelopment ofthe Los Angeles Basin Clinical and Translational Science Institute (CTSI). Our vision is toimprove health ofthe diverse and underserved population of urban Los Angeles and, in doing so, to gainknowledge that we can share with others to improve health in urban settings and megacities across theglobe. In pursuit of that vision, we have established a unique partnership of leading academic, clinical andcommunity health organizations in the urban heart of Los Angeles. We are transforming this partnership intoa preeminent clinical and translational science institute focused on better heath for diverse, urbancommunities. We have established four main goals for the CTSI: abuild on many independent strengths tocreate an integrated academic home that places high priority on clinical and translational science; acreatenew translational research teams and conduct projects that leverage our unique populations andpartnerships to address the best scientific opportunities and most important health priorities of our localcommunities; Btransform education and training to create a cadre of people with a major career focus onclinical and translational research;
and aim plement and disseminate what we learn to improve health in ourlocal communities and advance translational research through regional and national networks andcollaborations. To achieve these goals, we have assembled an exceptional leadership team that is creatingthrough the CTSI: aoutstanding resources for active development of new research projects and teams, aarobust infrastructure to promote and support basic, clinical and community research, acutting edgemethodologies for data acquisition, integration, management and analysis; aintegrated training of basic,clinical and community researchers using distance education and a focus on research for the diversecommunities; aa novel approach to dissemination of our findings using professional communicationsexpertise; and aa professional evaluation group to track and evaluate our progress and impact. Using $3.3Mof institutional support, we have already made significant progress in transforming our local environment to ahome that highly values clinical and translational research. We demonstrate strong ability to generate andsupport exciting new research, from the bench to our communities. With a CTSA and a pledge of $18.7M ofinstitutional support over five vears, we will expand to a fully functional institute that will have a have a majorimpact to improve urban health and advance the discipline of clinical and translational research.
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