Program Director/Principal Investigator (Last, First, Middle): Joseph, Jill G.After a decade of remarkable research growth and institutional investment, Children's National Medical Center(CNMC) builds on significant strategic recruitments, reorganizations, and collaborations required to create thetransformative capabilities of the Clinical and Translational Science Institute at Children's National (CTSI-CN).It has done so in partnership with its academic affiliate, the George Washington University. The specificobjectives of our application are to: 1) Provide state-of-the-art, flexible resources required by CTR investigators;2) Promote multidisciplinary clinical and translational research (CTR); 3) Strengthen CTR education andtraining for diverse trainees at all stages of career development; 4) Promote demographic diversity and addresshealth disparities; 5) Incorporate effective and sustained collaboration with community partners; 6) Assureefficiency of CTR from conceptualization through dissemination; and 7) Establish bi-directional collaborationswith the CTSA network. The CTSI-CN has innovative features including: a child health focus, especiallyemphasizing health disparities and childhood antecedents of adult diseases; our relationship with a nationalnetwork of 1200 community health centers, and in TI strengths in rare diseases and neurodevelopmentaldisabilities. We have combined certain related CTSA components to provide more closely integrated,investigator-focused capabilities. Biomedical Informatics (BI): provides the backbone informatics support to allCTSI-CN components. Research Education, Training and Career Development (RETCD) integrates,supports, and expands CTR education and training so that it is available from high school through mid-career.A new degree program (MS in CTR) and a certificate program are complemented by diverse educationalopportunities for faculty, trainees, and staff at all levels of experience. Specialized programs are available formid-level faculty to promote their career advancement and mentoring capabilities, and for underrepresentedminority undergraduates potentially interested in a career in CTR. Community Engagement andResearch/Health Policy (CER/HP) integrates traditional community engagement/research with nationallyrecognized health policy capabilities. Participant and Clinical Interactions Resources (PCIR) transforms ourexisting GCRC into a nimble and innovative resource that supports participant interactions at diverse locationsincluding CNMC, outpatient facilities, GW, and the community. Pilot and Collaborative Translational andClinical Studies: supports transfomiative ideas by investigators at all career levels. Novel Clinical andTranslational Methodologies (NCTM) identifies needs and gaps and supports development of innovativemethodologies, especially to support TTR cores. Research Design. Epidemiology, Biostatistics, and ClinicalResearch Ethics/Regulatory Knowledge and Support (DBE/RKS): provides integrated, investigator-focusedresources to assure the quality of research and the protection of human subjects at all stages of research.Translational Technologies and Resources (TTR) supports a diverse group of 15 core functions. Tracking andEvaluation (TE): CTSI-CN activities will be guided and modified by a thoughtful and detailed evaluation plan.
(See Instructions):The CTSI-CN provides highly integrated, cost effective, investigator-focused resources designed to overcomeobstacles to investigation, promote collaborative research, and be continuously monitored and evaluated toidentify when further adaptation or modification is needed. Located in the nation's capital and serving apopulation of children and families disproportionately affected by health disparities, the CTSI-CN brings to bearunique resources in translating discovery to improved health, particularly in our most disadvantagedpopulations of children.
|Anderson, Julia; Seol, Haeri; Gordish-Dressman, Heather et al. (2017) Interleukin 1 Receptor-Like 1 Protein (ST2) is a Potential Biomarker for Cardiomyopathy in Duchenne Muscular Dystrophy. Pediatr Cardiol 38:1606-1612|
|Brelsford, Jill B; Plieskatt, Jordan L; Yakovleva, Anna et al. (2017) Advances in neglected tropical disease vaccines: Developing relative potency and functional assays for the Na-GST-1/Alhydrogel hookworm vaccine. PLoS Negl Trop Dis 11:e0005385|
|Li, Peijun; Fu, Xiaoqin; Smith, Nathan A et al. (2017) Loss of CLOCK Results in Dysfunction of Brain Circuits Underlying Focal Epilepsy. Neuron 96:387-401.e6|
|Vaughns, Janelle D; Ziesenitz, Victoria C; Williams, Elaine F et al. (2017) Use of Fentanyl in Adolescents with Clinically Severe Obesity Undergoing Bariatric Surgery: A Pilot Study. Paediatr Drugs 19:251-257|
|Stokes, Bethany A; Sabatino, Julia A; Zohn, Irene E (2017) High levels of iron supplementation prevents neural tube defects in the Fpn1ffe mouse model. Birth Defects Res 109:81-91|
|Warrier, Sunita; Nuwayhid, Samer; Sabatino, Julia A et al. (2017) Supt20 is required for development of the axial skeleton. Dev Biol 421:245-257|
|Govindan, R B; Massaro, An; Vezina, Gilbert et al. (2017) Does relative or absolute EEG power have prognostic value in HIE setting? Clin Neurophysiol 128:14-15|
|Lee, B; Diaz, G A; Rhead, W et al. (2016) Glutamine and hyperammonemic crises in patients with urea cycle disorders. Mol Genet Metab 117:27-32|
|Kota, Srinivas; du Plessis, Adre; Massaro, An N et al. (2016) A frequency based spatial filter to mitigate volume conduction in electroencephalogram signals. Conf Proc IEEE Eng Med Biol Soc 2016:4001-4004|
|Schweitzer, Amy L; Ross, Jamisha T; Klein, Catherine J et al. (2016) An Electronic Wellness Program to Improve Diet and Exercise in College Students: A Pilot Study. JMIR Res Protoc 5:e29|
Showing the most recent 10 out of 116 publications