The CTSA has transformed UT Southwestern's clinical research and education Infrastructures in a mere 3.5years. The UT Southwestern Clinical and Translational Alliance for Research (UT-STAR) CTSA will build onthis foundation and make further transformative changes to improve and accelerate the pace at whichbiomedical discoveries are translated to positively impact the health of North and Central Texas and ournation. Our bold approaches will be based on the following new goals: 1) Catalyze translation bybroadening the scope, depth and quality of all key functions. These include establishing an alliance of theUT-STAR leadership across the entire T1-T4 spectrum of translational science; creating a new Phase IClinical Trials program; deploying integrated information technology platforms to enable large-scale clinicaltrials, comparative effectiveness research (CER) and population- and community-based studies;revolutionizing our Clinical and Translational Research Center by incorporating the Dallas Heart Studyinfrastructure and database, creating new blood and tissue biobanks, and implementing more effectivestrategies to increase participation of underserved populations including children and underrepresentedminorities in clinical and translational research; 2) Train translational scientists by developing neweducation programs for Clinical Research Scholars and MSc degree candidates that include an innovativeTl/Phase I Trials training track and expanded instruction in CER and community engagement research. Wewill also extend MSc-level training in Clinical Sciences to translational PhD students enrolled in our HowardHughes Medical Institute-supported Med to Grad program; 3) Stimulate innovation in TranslationalScience by establishing a 'real time' repository of potential research participants for large-scale clinical trials(T2), using emerging digital technologies to improve research communication, novel imaging technologies toadvance phenotyping of common diseases including cancer, cardiovascular and neuropsychiatric illnesses,and developing a large community-based blood bank program to launch new studies in CER (T3) andpopulation science (T4); and 4) Advance community-engaged research bv establishing new partnershipswith both urban and rural communities to enhance fair and equitable opportunities for community members'participation in research; deploying electronic medical record systems to engender: a) participation ofunderrepresented minorities in community-based participatory research and b) interactions with localpractitioners to build confidence and relationships that facilitate recruitment into research studies.
Improving the health of our nation requires a concerted effort by medical scientists, health care providers andpublic health policymakers. This grant application will provide the crucial infrastructure necessary formedical scientists to discover and apply new diagnostics and therapeutics for the detection, diagnosis,treatment and prevention of disease, and thereby achieve the goal of improving our nation's health in a safe,ethical and responsible manner that ensures the individual's well-being and the public's trust.
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