Contact PD/PI: COOPER, DAN M Our driving aim is to tangibly benefit health through fundamental translational science discovery, implementation, and training. The UCI Institute for Clinical and Translational Science (ICTS) will enable a wide range of translational research conducted at our institution and in our region in an environment of exceptional quality, safety and efficiency. We will empower programs and talent unique to our Hub that will foster innovation and continuous improvement enriching the entire national network. We will create and track novel programs in each of the essential areas outlined by NCATS: 1) Workforce Development: Trainees (at both the K and NRSA levels) will harness strengths at UCI, including existing immersive training programs in areas such as systems biology that can shorten and improve the training experience. Community-university externships will provide wide-ranging experiential learning including ?health and the judicial system? and ?drug discovery in local start-ups.? Our clinical trainees will play an integral role in workforce development of all staff, such as our recently developed certification program for study coordinators. Particular talent at UCI in both the science and implementation of team science resulted in a Team Science Core Curriculum, which will be integrated into all ICTS training. 2) Collaboration and Engagement: The ICTS ecosystem is one in which our academic health center actively collaborates with regional partners: the freestanding Children?s Hospital of Orange County (CHOC), the local VA, and a growing community-based accountable care organization in our region. The ICTS will lead an institutional and regional effort to improve quality and efficiency, preparing us as a Hub poised to excel in multicenter clinical investigations. By engaging the successful clinical trial experience of our faculty, building on years of effective community outreach, our integration with community clinics, and advanced EHR cohort discovery tools, the clinical trials Accrual and Retention Core is designed to optimally recruit from the youngest of the young (premature babies) to the oldest of the old (90+), and from typically underrepresented groups in clinical research. 3) Integration: Child health research will be fostered through: collaborations with the AAP Pediatric Research in Office Settings network; a formal Research Strategic Plan with CHOC; and through an Optional Module with nineteen other CTSAs (Child Health Research Acceleration through Multisite Planning). 4) Methods and Processes: Our involvement with the consortium of the five UC CTSAs (BRAID?Biomedical Research Acceleration Integration and Development) has served as a testing ground of novel approaches for multisite research. BRAID-initiated Trust-and-Rely IRB and the UC-Research Exchange cohort discovery tool are being integrated into the NCATS ACT project. Building on UCI strengths in exercise medicine, the Terminology Harmonization in Exercise Medicine and Exercise Science (an Optional Module) will transform the use of exercise biomarkers in clinical research. In sum, translational research will thrive in this environment where ?everything is questioned and there is no status quo.? Project Summary/Abstract Page 129 Contact PD/PI: COOPER, DAN M

Public Health Relevance

The challenges of diminishing resources for support of health care discovery can only be addressed by aligning the research and clinical missions of academic health centers in unprecedented ways. Our CTSA Hub is poised to transform clinical research in our region with novel training in collaborative team science; support for early phase transformative research; and by catalyzing partnerships with community and industry. We will link the creative energy of investigators at our Hub with the national network of CTSAs. As a result, potential advances in health will be studied in an environment of exceptional safety and quality, and reach the public as rapidly as possible. Project Narrative Page 130

National Institute of Health (NIH)
National Center for Advancing Translational Sciences (NCATS)
Linked Specialized Center Cooperative Agreement (UL1)
Project #
Application #
Study Section
Special Emphasis Panel (ZTR1-SRC (99))
Program Officer
Merchant, Carol
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of California Irvine
Schools of Medicine
United States
Zip Code
Elsensohn, Ashley; Getty, Sasha; Shiu, Jessica et al. (2018) Intradermal Proliferative Fasciitis Occurring With Chondrodermatitis Nodularis Helicis. Am J Dermatopathol 40:139-141
Adams, Tayloria N G; Jiang, Alan Y L; Vyas, Prema D et al. (2018) Separation of neural stem cells by whole cell membrane capacitance using dielectrophoresis. Methods 133:91-103
Sorkin, Dara H; Amin, Alpesh; Weimer, David L et al. (2018) Hospital Discharge and Selecting a Skilled Nursing Facility: A Comparison of Experiences and Perspectives of Patients and Their Families. Prof Case Manag 23:50-59
Aggarwal, Sahil; Kheriaty, Aaron (2018) Same behavior, different provider: American medical students' attitudes toward reporting risky behaviors committed by doctors, nurses, and classmates. AJOB Empir Bioeth 9:12-18
Valdebran, Manuel; Bandino, Justin; Elbendary, Amira et al. (2018) Nuclear and cytoplasmic features in the diagnosis of Clark's nevi. J Cutan Pathol 45:204-207
Radom-Aizik, Shlomit; Zaldivar, Frank P; Nance, Dwight M et al. (2018) A Translational Model of Incomplete Catch-Up Growth: Early-Life Hypoxia and the Effect of Physical Activity. Clin Transl Sci 11:412-419
Pouldar, Delila; Elsensohn, Ashley; Ortenzio, Francesca et al. (2018) Nodular Vasculitis in a Patient With Crohn's Disease on Vedolizumab. Am J Dermatopathol 40:e36-e37
Sujatha-Bhaskar, Sarath; Jafari, Mehraneh D; Hanna, Mark et al. (2018) An endoscopic mucosal grading system is predictive of leak in stapled rectal anastomoses. Surg Endosc 32:1769-1775
Pugh, Sarah J; Hinkle, Stefanie N; Kim, Sungduk et al. (2018) Combined Influence of Gestational Weight Gain and Estimated Fetal Weight on Risk Assessment for Small- or Large-for-Gestational-Age Birth Weight: A Prospective Cohort Study. J Ultrasound Med 37:935-940
Treem, Jeffrey W; Schneider, Margaret; Zender, Robynn L et al. (2018) Exploring the potential role of community engagement in evaluating clinical and translational science grant proposals. J Clin Transl Sci 2:139-146

Showing the most recent 10 out of 488 publications