The vision of the Center for Clinical and Translational Science and Training (CCTST) at the University of Cincinnati is to be the Greater Cincinnati portal of entry for support of clinical and translational research with a goal to enfranchise stakeholders from a broad base to integrate research into healthcare delivery, improve community wellness, foster effective, efficient multisite trials, and train the clinical and translational research workforce of the future. We will realize this vision through three aims: (1) Empower stakeholders in the process of integrating research with healthcare practice and community wellness, (2) Create the workforce of the future, and (3) Optimize efficiency and effectiveness of clinical research. Building on the successes of the last 6 years, we propose innovative changes to existing programs and creation of new programs designed to provide support for high quality cutting-edge research done by teams of scientists. Building on our existing programs, we propose to (1) provide innovative programs in career development for a wide range of learners, (2) develop new pilot programs to support creation of solutions for obstacles to research, (3) expand our community engagement program to extend beyond Greater Cincinnati to stakeholders across the U.S., (4) provide more comprehensive support by biomedical informatics for the services provided by the CCTST, (5) expand support for patient-oriented research, and (6) help overcome regulatory and ethical challenges that impede clinical research in local and multisite studies. We propose innovative efforts directed toward fostering learning health networks and creating a Research Commons to provide more comprehensive support to investigators. We will focus on (1) teaching and implementing team science principles and encouraging collaboration across a variety of disciplines and stakeholders, (2) consolidation of clinical trials support across the academic health center by creating Cinci-HERO to help multicenter trials for which the CCTST affiliates are the leads (including serving as the IRB of record) or site participants and recruitment of populations across the lifespan including underrepresented minorities, those with environmental exposures and health disparities, and (3) acute care research and lifespan data integration that takes advantage of institutional strengths.

Public Health Relevance

The maturation of the CTSA consortium has led to more effective and efficient clinical and translational research across the 62 sites. The University of Cincinnati Center for Clinical and Translational Science and Training has already been successful at fostering and become the focal point for clinical and translational research in Cincinnati. With this renewal application, we will develop additional innovative methods to produce high quality research, share these discoveries, and collaborate with other CTSA hubs.

Agency
National Institute of Health (NIH)
Institute
National Center for Advancing Translational Sciences (NCATS)
Type
Linked Specialized Center Cooperative Agreement (UL1)
Project #
1UL1TR001425-01
Application #
9085664
Study Section
Special Emphasis Panel (ZTR1-SRC (99))
Program Officer
Merchant, Carol
Project Start
2015-08-14
Project End
2019-03-31
Budget Start
2015-08-14
Budget End
2016-03-31
Support Year
1
Fiscal Year
2015
Total Cost
$3,187,599
Indirect Cost
$513,333
Name
University of Cincinnati
Department
Pediatrics
Type
Schools of Medicine
DUNS #
041064767
City
Cincinnati
State
OH
Country
United States
Zip Code
45221
Doss, Laura M; Dandoy, Christopher E; Kramer, Kathi et al. (2018) Oral health and hematopoietic stem cell transplantation: A longitudinal evaluation of the first 28 days. Pediatr Blood Cancer 65:
Goldstein, Bryan H; Goldstein, Stuart L; Devarajan, Prasad et al. (2018) First-stage palliation strategy for univentricular heart disease may impact risk for acute kidney injury. Cardiol Young 28:93-100
Schwartz, Beth I; Huppert, Jill S; Chen, Chen et al. (2018) Creation of a Composite Score to Predict Adnexal Torsion in Children and Adolescents. J Pediatr Adolesc Gynecol 31:132-137
Rutter, Michael J; Hart, Catherine K; Alarcon, Alessandro de et al. (2018) Endoscopic anterior-posterior cricoid split for pediatric bilateral vocal fold paralysis. Laryngoscope 128:257-263
Gloude, Nicholas J; Jodele, Sonata; Teusink-Cross, Ashley et al. (2018) Combination of High-Dose Methylprednisolone and Defibrotide for Veno-Occlusive Disease in Pediatric Hematopoietic Stem Cell Transplant Recipients. Biol Blood Marrow Transplant 24:91-95
Guo, Jinbang; Cao, Xuefeng; Cleveland, Zackary I et al. (2018) Murine pulmonary imaging at 7T: T2* and T1 with anisotropic UTE. Magn Reson Med 79:2254-2264
Fox, Robert J; Coffey, Christopher S; Conwit, Robin et al. (2018) Phase 2 Trial of Ibudilast in Progressive Multiple Sclerosis. N Engl J Med 379:846-855
Wink, Logan K; Pedapati, Ernest V; Adams, Ryan et al. (2018) Characterization of Medication Use in a Multicenter Sample of Pediatric Inpatients with Autism Spectrum Disorder. J Autism Dev Disord 48:3711-3719
Galloway, David; Mezoff, Ethan; Zhang, Wujuan et al. (2018) Serum Unconjugated Bile Acids and Small Bowel Bacterial Overgrowth in Pediatric Intestinal Failure: A Pilot Study. JPEN J Parenter Enteral Nutr :
Agarwal, S; Raymond, J K; Isom, S et al. (2018) Transfer from paediatric to adult care for young adults with Type 2 diabetes: the SEARCH for Diabetes in Youth Study. Diabet Med 35:504-512

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