Contact PD/PI: Brady, Kathleen Theresa OVERALL: PROJECT SUMMARY As part of the CTSA consortium since 2009, the South Carolina Translational and Clinical Research Institute (SCTR) created an academic home for clinical and translational research in South Carolina that has transformed the research environment across the state with the goal of accelerating efficient translation of biomedical discoveries into improvements in human health. Headquartered at the Medical University of South Carolina (MUSC) in Charleston, SCTR created a ?front door? for access to statewide research resources, providing more than 700 direct consultations and innumerable website ?hits? each year. We successfully engaged local and regional stakeholder communities in facilitating and guiding research, implementation and dissemination activities. We catalyzed the formation of interdisciplinary research teams through innovative translational pilot projects and integrated training programs. We worked across the state and with national CTSA colleagues to streamline and improve efficiencies in research processes, including the development of a research service ordering and fulfillment system (SPARC) that is deployed within SCTR and four other CTSA hubs. A major focus of this renewal application is to advance Learning Health System (LHS) principles by: (a) providing real-time access to data to guide decision-making and continuous quality improvement efforts, (b) facilitating robust relationships with patients and other stakeholders to ensure clinical and translational research relevance, and (c) fostering a culture of collaboration, teamwork and adaptability. We will work with SCTR affiliates in South Carolina and collaborate with the CTSA Network to achieve the following specific aims: 1) Build on our clinical and translational research strengths to enrich and expand our integrated, statewide research environment and expand our CTSA Network collaborations; 2) Develop and implement high quality, innovative, flexible curricula and training experiences for all levels of the translational research workforce with a focus on enhancing diversity and advancing team science; 3) Promote community engagement throughout the translational research continuum and facilitate robust relationships with patients and other stakeholders to ensure CTR relevance; 4) Create an efficient enterprise-wide clinical and translational research ?Quality System? driven by continuous quality improvement and innovation; and 5) Promote the engagement of diverse populations across the lifespan in clinical and translational research. Project Summary/Abstract Page 279 Contact PD/PI: Brady, Kathleen Theresa

Public Health Relevance

The South Carolina Clinical & Translational Research Institute (SCTR) has established strong training and infrastructure resources with the goal of accelerating efficient translation of biomedical research into improvements in human health. A major focus of this application is to continue to foster a culture of collaboration, teamwork and adaptability among scientists, health professionals and community members across South Carolina and beyond as part of a national network to ensure that scientific discovery is relevant and rapidly translated to front-line treatment settings for maximum impact on health outcomes. Project Narrative Page 280

National Institute of Health (NIH)
National Center for Advancing Translational Sciences (NCATS)
Linked Specialized Center Cooperative Agreement (UL1)
Project #
Application #
Study Section
Special Emphasis Panel (ZTR1)
Program Officer
Purucker, Mary E
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Medical University of South Carolina
Schools of Medicine
United States
Zip Code
Agarwal, S; Raymond, J K; Isom, S et al. (2018) Transfer from paediatric to adult care for young adults with Type 2 diabetes: the SEARCH for Diabetes in Youth Study. Diabet Med 35:504-512
Heckman, Bryan W; Dahne, Jennifer; Germeroth, Lisa J et al. (2018) Does cessation fatigue predict smoking-cessation milestones? A longitudinal study of current and former smokers. J Consult Clin Psychol 86:903-914
Bade, Brett C; Brooks, Mary C; Nietert, Sloan B et al. (2018) Assessing the Correlation Between Physical Activity and Quality of Life in Advanced Lung Cancer. Integr Cancer Ther 17:73-79
Bade, Brett C; Hyer, J Madison; Bevill, Benjamin T et al. (2018) A Patient-Centered Activity Regimen Improves Participation in Physical Activity Interventions in Advanced-Stage Lung Cancer. Integr Cancer Ther 17:921-927
Wilmskoetter, Janina; Martin-Harris, Bonnie; Pearson Jr, William G et al. (2018) Differences in swallow physiology in patients with left and right hemispheric strokes. Physiol Behav 194:144-152
Worley, Mitchell L; Patterson, Travis M; Graboyes, Evan M et al. (2018) Association of the Anterolateral Thigh Osteomyocutaneous Flap With Femur Structural Integrity and Assessment of Prophylactic Fixation. JAMA Otolaryngol Head Neck Surg 144:769-775
Price, Matthew; Lancaster, Cynthia Luethcke; Gros, Daniel F et al. (2018) An Examination of Social Support and PTSD Treatment Response During Prolonged Exposure. Psychiatry 81:258-270
Pandey, Janardan P; Namboodiri, Aryan M; Wolf, Bethany et al. (2018) Endogenous antibody responses to mucin 1 in a large multiethnic cohort of patients with breast cancer and healthy controls: Role of immunoglobulin and Fc? receptor genes. Immunobiology 223:178-182
Tomko, Rachel L; Gilmore, Amanda K; Gray, Kevin M (2018) The role of depressive symptoms in treatment of adolescent cannabis use disorder with N-Acetylcysteine. Addict Behav 85:26-30
López, Cristina M; Qanungo, Suparna; Jenkins, Carolyn et al. (2018) Technology as a Means to Address Disparities in Mental Health Research: A Guide to ""Tele-Tailoring"" your Research Methods. Prof Psychol Res Pr 49:57-64

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