? SCTR INSTITUTE Parent Award UL1-TR001450 Since 2009, the South Carolina Clinical and Translational Research Institute (SCTR) has transformed the research environment across South Carolina (SC) by creating a Learning Health System that supports high- quality clinical and translational research (CTR) and fosters collaboration and innovation. Headquartered at the Medical University of South Carolina (MUSC), SCTR has engaged stakeholders and created statewide partnerships to improve care and address social determinants of health across SC. However, greater than 75% of SC is rural, and all 46 counties contain areas designated as medically underserved, so health disparities remain an issue. Over the next five years, SCTR will strengthen its outreach to these medically underserved areas through collaboration with the Clemson University Health Extension Program and the MUSC Telehealth Center of Excellence. With a focus on implementation and dissemination as well as discovery, we will develop and demonstrate innovative technologies and outreach to improve the health of our stakeholders. We will build on prior successes and introduce innovative approaches to expand CTR across SC through the following aims:
Aim 1. Extend and enhance high-quality, innovative, flexible curricula and training experiences for all levels of the CTR workforce, with particular emphasis on enhancing workforce heterogeneity and team science.
Aim 2. Engage a diverse group of stakeholders as active partners in CTR to address health care priorities while enhancing the scientific knowledge base about collaboration and engagement.
Aim 3. Promote greater inclusion across the full translational spectrum of research by engaging investigators from many disciplines and patient populations from diverse demographic backgrounds and geographic areas.
Aim 4. Develop, demonstrate and disseminate innovative methods and processes to address barriers and accelerate the translation of research discoveries to improvements in human health that can be generalized to a variety of practice settings.
Aim 5. Enhance the conduct of translational research through the development of secure and innovative informatics and digital health solutions, tools and methodologies that affect every aspect of CTR. SCTR?s vision is to be a major force in facilitating the translation of innovative science into practice to address the health priorities of the citizens of SC and beyond. To achieve this vision, SCTR?s mission is to catalyze the development of methods and technologies that lead to more efficient translation of biomedical discoveries into interventions that improve individual and public health. SCTR will serve as the statewide academic home for CTR, one that is well-integrated with SC?s healthcare systems and provides essential support for innovative, efficient, multidisciplinary research and research training. We will work within SCTR, with our partners across SC and with the CTSA Consortium to realize this vision.

Public Health Relevance

The South Carolina Clinical and Translational Research Institute (SCTR) has transformed the research environment across South Carolina by creating a Learning Health System characterized by strong training and infrastructure resources that stimulate collaboration and innovation as a means to accelerate the translation of biomedical research discoveries into human health improvements. A major focus of this application is to strengthen SCTR?s statewide collaborations through innovative partnerships and initiatives with an emphasis on rural and medically underserved communities where significant health disparities exist. We will develop, demonstrate and disseminate innovative ways to train a diverse workforce and address barriers to translational research, and we will continue to collaborate across the CTSA Consortium to maximize impact and improve the health of the nation.

Agency
National Institute of Health (NIH)
Institute
National Center for Advancing Translational Sciences (NCATS)
Type
Linked Specialized Center Cooperative Agreement (UL1)
Project #
3UL1TR001450-06S2
Application #
10200510
Study Section
Program Officer
Gopal-Srivastava, Rashmi
Project Start
2020-09-04
Project End
2025-03-31
Budget Start
2020-09-04
Budget End
2021-03-31
Support Year
6
Fiscal Year
2020
Total Cost
Indirect Cost
Name
Medical University of South Carolina
Department
Psychiatry
Type
Schools of Medicine
DUNS #
183710748
City
Charleston
State
SC
Country
United States
Zip Code
29407
Zuschlag, Zachary D; Korte, Jeffrey E; Hamner, Mark (2018) Predictors of Lifetime Suicide Attempts in Individuals With Attenuated Psychosis Syndrome. J Psychiatr Pract 24:169-178
Zhou, Yue; Li, Pengfei; Goodwin, Andrew J et al. (2018) Exosomes from Endothelial Progenitor Cells Improve the Outcome of a Murine Model of Sepsis. Mol Ther 26:1375-1384
Lewis, Morag A; Nolan, Lisa S; Cadge, Barbara A et al. (2018) Whole exome sequencing in adult-onset hearing loss reveals a high load of predicted pathogenic variants in known deafness-associated genes and identifies new candidate genes. BMC Med Genomics 11:77
Mulligan, Jennifer K; Patel, Kunal; Williamson, Tucker et al. (2018) C3a receptor antagonism as a novel therapeutic target for chronic rhinosinusitis. Mucosal Immunol 11:1375-1385
West, Natalie E; Flume, Patrick A (2018) Unmet needs in cystic fibrosis: the next steps in improving outcomes. Expert Rev Respir Med 12:585-593
Hatch, Jonathan L; Schopper, Heather; Boersma, Isabel M et al. (2018) The Bone Mineral Density of the Lateral Skull Base and its Relation to Obesity and Spontaneous Cerebrospinal Fluid Leaks. Otol Neurotol 39:e831-e836
McRackan, Theodore R; Fabie, Joshua E; Burton, Jane A et al. (2018) Earphone and Aided Word Recognition Differences in Cochlear Implant Candidates. Otol Neurotol 39:e543-e549
Muhammad, Lutfiyya N; Korte, Jeffrey E; Bowman, Charles M et al. (2018) The Effects of Asthma and Bullying on Suicidal Behaviors Among US Adolescents. J Sch Health 88:762-767
Taylor, Robert J; Schlosser, Rodney J; Soler, Zachary M et al. (2018) Glucocorticoid receptor isoform expression in peripheral blood mononuclear leukocytes of patients with chronic rhinosinusitis. Int Forum Allergy Rhinol :
Kimbrough, Denise; Wang, Sabina H; Wright, Lillianne H et al. (2018) HDAC inhibition helps post-MI healing by modulating macrophage polarization. J Mol Cell Cardiol 119:51-63

Showing the most recent 10 out of 228 publications