EFFECTIVE ALLOCATION OF TEST CENTERS FOR COVID-19 USING MACHINE LEARNING AND ADAPTIVE SAMPLING ABSTRACT A critical task in managing and dealing with COVID-19 in communities is to perform diagnostic and/or antibody tests to identify diseased individuals. This information is critical to public health officials to estimate prevalence and transmission, and to effectively plan for required resources such as ICU beds, ventilators, personal protective equipment, and medical staff. Additionally, information on the number of infected people can be used to develop probabilistic and statistical models to estimate the reproduction number of the disease, and to predict the likely spatial and temporal trajectories of the outbreak. This provides vital information for planning actions and preparing policies and guidelines for social-distancing, school closures, remote work, community lockdown, etc. Despite the importance of diagnostic testing and identification of the positive cases, broad-scale testing is a challenging task particularly due to the limited number of test kits and resources. Our proposed research focuses on the development machine learning-based allocation strategies for determining the optimal location of COVID-19 test centers, including mobile and satellite centers, to minimize the local and global prediction uncertainties, maximize geographic coverage, associated with projections of spatio-temporal outbreak trajectories, and to improve efficient identification of diseased cases.

Public Health Relevance

EFFECTIVE ALLOCATION OF TEST CENTERS FOR COVID-19 USING MACHINE LEARNING AND ADAPTIVE SAMPLING NARRATIVE Diagnostic and antibody tests for COVID-19 can provide invaluable information on prevalence and transmission of the disease. However, due to limited test capacity, broad-scale testing is currently not feasible. Consequently, there is a pressing need for a systematic and data-driven approach to defining testing strategies, in particular, determining the number and location of satellite and mobile testing centers (e.g., drive-through test locations). Our research program develops machine learning approaches to effectively allocate test centers for COVID-19 at the city, county, and state levels to accurately and reliably estimate the disease prevalence and its trajectory for resource planning and policy making, and to efficiently identify cases for treatment.

Agency
National Institute of Health (NIH)
Institute
National Center for Advancing Translational Sciences (NCATS)
Type
Linked Specialized Center Cooperative Agreement (UL1)
Project #
3UL1TR002378-04S2
Application #
10158891
Study Section
Special Emphasis Panel (ZTR1)
Program Officer
Davis Nagel, Joan
Project Start
2017-09-22
Project End
2022-06-30
Budget Start
2020-08-01
Budget End
2021-06-30
Support Year
4
Fiscal Year
2020
Total Cost
Indirect Cost
Name
Emory University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
066469933
City
Atlanta
State
GA
Country
United States
Zip Code
30322
Chinnadurai, Raghavan; Rajan, Devi; Qayed, Muna et al. (2018) Potency Analysis of Mesenchymal Stromal Cells Using a Combinatorial Assay Matrix Approach. Cell Rep 22:2504-2517
Dunlop, Boadie W; Cole, Steven P; Nemeroff, Charles B et al. (2018) Differential change on depressive symptom factors with antidepressant medication and cognitive behavior therapy for major depressive disorder. J Affect Disord 229:111-119
Serota, David P; Franch, Harold A; Cartwright, Emily J (2018) Acute Kidney Injury in a Patient on Tenofovir Alafenamide Fumarate After Initiation of Treatment for Hepatitis C Virus Infection. Open Forum Infect Dis 5:ofy189
Graciaa, D S; Machaidze, M; Kipiani, M et al. (2018) A survey of the tuberculosis physician workforce in the country of Georgia. Int J Tuberc Lung Dis 22:1286-1292
Gopalsamy, Srinivasa Nithin; Sherman, Amy; Woodworth, Michael H et al. (2018) Fecal Microbiota Transplant for Multidrug-Resistant Organism Decolonization Administered During Septic Shock. Infect Control Hosp Epidemiol 39:490-492
Hohos, Natalie M; Smith, Alicia K; Kilaru, Varun et al. (2018) CD4+ and CD8+ T-Cell-Specific DNA Cytosine Methylation Differences Associated With Obesity. Obesity (Silver Spring) 26:1312-1321
Squires, Alexander; Oshinski, John N; Boulis, Nicholas M et al. (2018) SpinoBot: An MRI-Guided Needle Positioning System for Spinal Cellular Therapeutics. Ann Biomed Eng 46:475-487
Morris, Claudia R; Mauger, David T; Suh, Jung H et al. (2018) Glutathione and arginine levels: Predictors for acetaminophen-associated asthma exacerbation? J Allergy Clin Immunol 142:308-311.e9
Burke, Rachel M; Rebolledo, Paulina A; Aceituno, Anna M et al. (2018) Effect of infant feeding practices on iron status in a cohort study of Bolivian infants. BMC Pediatr 18:107
Woodworth, Michael H; Kraft, Colleen S; Meredith, Erika J et al. (2018) Tacrolimus concentration to dose ratio in solid organ transplant patients treated with fecal microbiota transplantation for recurrent Clostridium difficile infection. Transpl Infect Dis 20:e12857

Showing the most recent 10 out of 87 publications