Abstract

1.
SPECIFIC AIMS The CHAVI-ID Operations and Management Support Component, (OMSC) will serve as a resource to the entire CHAVI-ID, providing overall management, coordination and supervision ofthe program. The CHAVI-ID director, Bart Haynes will serve as the leader of the OMSC, and experienced OMSC staff will be responsible for managing and coordinating the entire range of CHAVI-ID activities, monitoring progress and ensuring that the CHAVI-ID Scientific Agenda and Strategic Plan is developed, renewed, and implemented effectively and efficiently.
Specific Aims will include the following.
Aim 1. Provide overall management, coordination and supervision of programs within CHAVI-ID to optimally facilitate HIV-1 vaccine discovery and development.
Aim 2. Ensure timely financial accounting in CHAVI-ID Aim 3. Ensure compliance with all institutional and federal research guidelines. Management of the CHAVI-ID will require remarkably complex and timely coordination of finances, program management, facilities, research and development activities, and investigators across disciplines and institutions. The expertise this group has gained over the past 6 years in CHAVI, will ensure success in the management of CHAVI-ID.

Public Health Relevance

Effective and timely financial and programmatic management are the key to the success for any scientific consortium. Ensuring the management of individual scientific projects, and having the ability to redirect funds in a timely manner as dictated by the science will facilitate HIV-1 vaccine development.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project with Complex Structure Cooperative Agreement (UM1)
Project #
1UM1AI100645-01
Application #
8385821
Study Section
Special Emphasis Panel (ZAI1-JBS-A (M1))
Project Start
Project End
Budget Start
2012-07-15
Budget End
2013-06-30
Support Year
1
Fiscal Year
2012
Total Cost
$7,471,727
Indirect Cost
$2,530,047

  Institution

Name
Duke University
Department
Type
DUNS #
044387793
City
Durham
State
NC
Country
United States
Zip Code
27705

  Publications

Fu, Qingshan; Shaik, Md Munan; Cai, Yongfei et al. (2018) Structure of the membrane proximal external region of HIV-1 envelope glycoprotein. Proc Natl Acad Sci U S A 115:E8892-E8899
Fera, Daniela; Lee, Matthew S; Wiehe, Kevin et al. (2018) HIV envelope V3 region mimic embodies key features of a broadly neutralizing antibody lineage epitope. Nat Commun 9:1111
McMichael, Andrew J (2018) Is a Human CD8 T-Cell Vaccine Possible, and if So, What Would It Take? Could a CD8+ T-Cell Vaccine Prevent Persistent HIV Infection? Cold Spring Harb Perspect Biol 10:
Williams, Wilton B; Han, Qifeng; Haynes, Barton F (2018) Cross-reactivity of HIV vaccine responses and the microbiome. Curr Opin HIV AIDS 13:9-14
Bonsignori, Mattia; Scott, Eric; Wiehe, Kevin et al. (2018) Inference of the HIV-1 VRC01 Antibody Lineage Unmutated Common Ancestor Reveals Alternative Pathways to Overcome a Key Glycan Barrier. Immunity 49:1162-1174.e8
Blasi, Maria; Negri, Donatella; LaBranche, Celia et al. (2018) IDLV-HIV-1 Env vaccination in non-human primates induces affinity maturation of antigen-specific memory B cells. Commun Biol 1:134
Song, Hongshuo; Giorgi, Elena E; Ganusov, Vitaly V et al. (2018) Tracking HIV-1 recombination to resolve its contribution to HIV-1 evolution in natural infection. Nat Commun 9:1928
Hurwitz, Julia L; Bonsignori, Mattia (2018) Multi-Envelope HIV-1 Vaccine Development: Two Targeted Immune Pathways, One Desired Protective Outcome. Viral Immunol 31:124-132
Yates, Nicole L; deCamp, Allan C; Korber, Bette T et al. (2018) HIV-1 Envelope Glycoproteins from Diverse Clades Differentiate Antibody Responses and Durability among Vaccinees. J Virol 92:
Castillo-Menendez, Luis R; Nguyen, Hanh T; Sodroski, Joseph (2018) Conformational Differences Between Functional Human Immunodeficiency Virus (HIV-1) Envelope Glycoprotein Trimers and Stabilized Soluble Trimers. J Virol :

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