The CHAVI-ID will be established as an integrated, priority-setting consortium with major components at multiple participating institutions and substantial NIH programmatic involvement in a collaborative partnership role with the Awardee to advance the science. Therefore, the Operations and Management Scientific Research Support Component (SRSC) is designed to function across institutional and geographic boundaries to provide the administrative activities that allow successful scientific collaboration and flow of resources. For efficiency of operations, the overall administrative and scientific management will be centralized, with the Operations and Management SRSC based at The Scripps Research Institute (TSRI), the Sponsoring Institution. The SRSC will be overseen by the CHAVI-ID Director and an on-site experienced Chief Operating Officer will dedicate 100% effort to managing CHAVI-ID administrative activities. An Operations Team will function on the premise of flexibility, as evolving scientific priorities and collaborative demands are to be expected during the extended period of the award. However, the flexibility will not be at the expense of efficiency or responsiveness to the needs of the collaborating scientific institutions. This management structure will effectively leverage the associated resources and program offices offered by TSRI.
The Specific Aims of the SRSC are:
Aim 1 : To establish a highly efficient operations and management structure that will provide essential support services to all CHAVI-ID investigators and leverage available resources at the sponsoring and collaborating institutions Aim 2: To assist the flow of information and scientific collaboration between CHAVI-ID Focus Teams by supporting meeting, teleconference, and information technology demands Aim 3: To implement the decisions of the CHAVI-ID Director and Leadership regarding direction of the Strategic Plan, allocation of future funding support, and changing composition of the group of collaborating CHAVI-ID scientists

Public Health Relevance

This SRSC offers efficient management of all CHAVI-ID operational issues to support successful scientific collaboration thereby advancing the Strategic Plan. A decision-making structure is established to ensure that the CHAVI-ID can respond to changing priorities as scientific discoveries are made and implement strategies to advance all phases of immunogen development.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project with Complex Structure Cooperative Agreement (UM1)
Project #
1UM1AI100663-01
Application #
8385912
Study Section
Special Emphasis Panel (ZAI1-JBS-A (M1))
Project Start
Project End
Budget Start
2012-07-15
Budget End
2013-06-30
Support Year
1
Fiscal Year
2012
Total Cost
$948,744
Indirect Cost
$195,200
Name
Scripps Research Institute
Department
Type
DUNS #
781613492
City
La Jolla
State
CA
Country
United States
Zip Code
92037
Keeffe, Jennifer R; Van Rompay, Koen K A; Olsen, Priscilla C et al. (2018) A Combination of Two Human Monoclonal Antibodies Prevents Zika Virus Escape Mutations in Non-human Primates. Cell Rep 25:1385-1394.e7
Havenar-Daughton, Colin; Sarkar, Anita; Kulp, Daniel W et al. (2018) The human naive B cell repertoire contains distinct subclasses for a germline-targeting HIV-1 vaccine immunogen. Sci Transl Med 10:
Cao, Liwei; Pauthner, Matthias; Andrabi, Raiees et al. (2018) Differential processing of HIV envelope glycans on the virus and soluble recombinant trimer. Nat Commun 9:3693
Niessl, Julia; Kaufmann, Daniel E (2018) Harnessing T Follicular Helper Cell Responses for HIV Vaccine Development. Viruses 10:
Crotty, Shane (2018) Do Memory CD4 T Cells Keep Their Cell-Type Programming: Plasticity versus Fate Commitment? Complexities of Interpretation due to the Heterogeneity of Memory CD4 T Cells, Including T Follicular Helper Cells. Cold Spring Harb Perspect Biol 10:
Struwe, Weston B; Chertova, Elena; Allen, Joel D et al. (2018) Site-Specific Glycosylation of Virion-Derived HIV-1 Env Is Mimicked by a Soluble Trimeric Immunogen. Cell Rep 24:1958-1966.e5
Burbage, Marianne; Gasparrini, Francesca; Aggarwal, Shweta et al. (2018) Tuning of in vivo cognate B-T cell interactions by Intersectin 2 is required for effective anti-viral B cell immunity. Elife 7:
Khan, Salar N; Sok, Devin; Tran, Karen et al. (2018) Targeting the HIV-1 Spike and Coreceptor with Bi- and Trispecific Antibodies for Single-Component Broad Inhibition of Entry. J Virol 92:
Niessl, Julia; Baxter, Amy E; Kaufmann, Daniel E (2018) Tools for Visualizing HIV in Cure Research. Curr HIV/AIDS Rep 15:39-48
Watanabe, Yasunori; Vasiljevic, Snezana; Allen, Joel D et al. (2018) Signature of Antibody Domain Exchange by Native Mass Spectrometry and Collision-Induced Unfolding. Anal Chem 90:7325-7331

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