This corresponds to mod Y1CO8110-01. The National Cancer Institute (NCI) Center for Bioinformatics (NCICB) provides biomedical informatics support and integration capabilities to the cancer research community. The Center works with both intramural and extramural groups to develop Initiative-Specific Modules. These modules are connected through intelligent interfaces, coordinated through an NCI Core Module and deployed through open source tools and systems. The NCICB also serves as a focal point for cancer research informatics planning worldwide. The Center works with research organizations, biomedical informatics groups and standards bodies to facilitate the identification and adoption of information exchange standards, thus connecting research information sources wherever they may reside.NCI Center for Bioinformatics (NCICB) is leading NCI's deployment of an integrating biomedical informatics infrastructure, the cancer Biomedical Informatics Grid (caBIG), to expedite the cancer research communities access to key bioinformatics platforms. In partnership with the cancer research community, the NC! is creating a common, extensible informatics platform that integrates diverse data types and supports interoperable analytic tools. This platform will allow research groups to tap into the rich collection of emerging cancer research data while supporting their individual investigations.One activity within the caBIG program includes the development and adoption of clinical trials tools and applications. One of these tools is Cancer Centralized Clinical Database System (C3DS). Another activity is the development of shared clinical research infrastructure called Mission Phoenix.NCI's C3DS enables the cancer research community to unify systems and data, and to improve work processes to better facilitate clinical trials activation and execution. Developed in a partnership between the NCI Center for Cancer Research (CCR), the NCI Center for Bioinformatics (NCICB), and commercial software vendors, C3DS provides the translational infrastructure to link laboratory data to clinical data.The heart of C3D is a library of standardized templates, electronic Case Report Forms (eCRFs) for collecting specific clinical protocols required data. These templates can be tailored for reuse across multiple studies, greatly accelerating the study implementation cycle.The caBIG initiative will enable development of a unifying approach facilitating cancer research progress. This will be accomplished through a network of researchers, tools, infrastructure, and data collaborating in an open environment with common standards. Mission Phoenix The National Cancer Institute (NC!), in collaboration with pharmaceutical companies and under the auspices of the Cancer Biomedical Informatics Grid (caBIG) and Inter Agency Task Force (IOTF) established between the NC! and Federal Drug Administration (FDA), is developing a standards-based, electronic clinical research exchange to support regulatory submissions. This initiative, called Mission Phoenix, will allow secure transmission of clinical research information between sponsors, researchers, and regulatory authorities; facilitate the adoption of electronic standards, e-transactions, and e-submissions; reduce the overall cost of existing information gathering and submissions development processes; and be accessible to all.
