The mission of the National Cancer Institute Center for Bloinformatics (NCICB) is to provide biomedical informatics infrastructure and scientific applications that support advanced translational research in cancer biology and medicine. REpository for Molecular BRAIn Neoplasia DaTa (Rembrandt) is targeted towards achieving this goal by making available to all investigators, a national molecular, genetic and clinical database of several thousand primary brain tumors. Rembrandt will be the vital link that will not only allow disparate types of data (pertaining to brain tumors) to be housed in a single system, but will also supply the bioinformatics tools critically necessary for the useful analyses of such data.Rembrandt Application: REMBRANDT is a robust bioinformatics knowledgebase framework that leverages data warehousing technology to host and integrate clinical and functional genomics data from clinical trials involving patients suffering from Gliomas. The knowledge framework provides researchers with the ability to perform ad hoc querying and reporting across multiple data domains, such as Gene Expression, Chrornosomal aberrations and Clinical data. Tools that link data to other annotations such as cellular pathways, gene ontology terms and genomic information are embedded.