Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Intramural Research (Z01)
Project #
1Z01AA000083-01
Application #
3745222
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
1
Fiscal Year
1994
Total Cost
Indirect Cost
Name
National Institute on Alcohol Abuse and Alcoholism
Department
Type
DUNS #
City
State
Country
United States
Zip Code
Brooks, P J (2008) The 8,5'-cyclopurine-2'-deoxynucleosides: candidate neurodegenerative DNA lesions in xeroderma pigmentosum, and unique probes of transcription and nucleotide excision repair. DNA Repair (Amst) 7:1168-79
Nakane, Hironobu; Hirota, Seiichi; Brooks, Philip J et al. (2008) Impaired spermatogenesis and elevated spontaneous tumorigenesis in xeroderma pigmentosum group A gene (Xpa)-deficient mice. DNA Repair (Amst) 7:1938-50
Brooks, P J; Cheng, Tsu-Fan; Cooper, Lori (2008) Do all of the neurologic diseases in patients with DNA repair gene mutations result from the accumulation of DNA damage? DNA Repair (Amst) 7:834-48
Gorodetsky, Elena; Calkins, Sarah; Ahn, Julia et al. (2007) ATM, the Mre11/Rad50/Nbs1 complex, and topoisomerase I are concentrated in the nucleus of Purkinje neurons in the juvenile human brain. DNA Repair (Amst) 6:1698-707
Theruvathu, Jacob A; Jaruga, Pawel; Dizdaroglu, Miral et al. (2007) The oxidatively induced DNA lesions 8,5'-cyclo-2'-deoxyadenosine and 8-hydroxy-2'-deoxyadenosine are strongly resistant to acid-induced hydrolysis of the glycosidic bond. Mech Ageing Dev 128:494-502
Brooks, P J (2007) The case for 8,5'-cyclopurine-2'-deoxynucleosides as endogenous DNA lesions that cause neurodegeneration in xeroderma pigmentosum. Neuroscience 145:1407-17
Marietta, Cheryl; Brooks, Philip J (2007) Transcriptional bypass of bulky DNA lesions causes new mutant RNA transcripts in human cells. EMBO Rep 8:388-93
Theruvathu, Jacob A; Jaruga, Pawel; Nath, Raghu G et al. (2005) Polyamines stimulate the formation of mutagenic 1,N2-propanodeoxyguanosine adducts from acetaldehyde. Nucleic Acids Res 33:3513-20
Brooks, Philip J; Theruvathu, Jacob A (2005) DNA adducts from acetaldehyde: implications for alcohol-related carcinogenesis. Alcohol 35:187-93
Jaruga, Pawel; Theruvathu, Jacob; Dizdaroglu, Miral et al. (2004) Complete release of (5'S)-8,5'-cyclo-2'-deoxyadenosine from dinucleotides, oligodeoxynucleotides and DNA, and direct comparison of its levels in cellular DNA with other oxidatively induced DNA lesions. Nucleic Acids Res 32:e87

Showing the most recent 10 out of 19 publications