During the past year, our research included: (1) studies of etiological mechanisms and behaviors associated with individual differences in alcohol consumption in rhesus monkeys; (2) studies of subjects selectively bred for target CSF 5-HIAA; (3) studies of other deficits in subjects with low CSF 5-HIAA; (4) studies of immune correlates of CSF 5-HIAA; (5) studies of treatment of spontaneous self-aggression; (6) studies of effect of rearing on maternal behavior; and (7) development of new technologies to study chronic alcohol consumption.

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Intramural Research (Z01)
Project #
1Z01AA000277-07
Application #
2333291
Study Section
Special Emphasis Panel (LCS)
Project Start
Project End
Budget Start
Budget End
Support Year
7
Fiscal Year
1996
Total Cost
Indirect Cost
Name
National Institute on Alcohol Abuse and Alcoholism
Department
Type
DUNS #
City
State
Country
United States
Zip Code
Lorenz, Joseph G; Long, Jeffrey C; Linnoila, Markku et al. (2006) Genetic and other contributions to alcohol intake in rhesus macaques (Macaca mulatta). Alcohol Clin Exp Res 30:389-98
Kumar, Rakesh; Perez-Casanova, Antonio E; Tirado, Grissell et al. (2005) Increased viral replication in simian immunodeficiency virus/simian-HIV-infected macaques with self-administering model of chronic alcohol consumption. J Acquir Immune Defic Syndr 39:386-90
Shannon, Courtney; Schwandt, Melanie L; Champoux, Maribeth et al. (2005) Maternal absence and stability of individual differences in CSF 5-HIAA concentrations in rhesus monkey infants. Am J Psychiatry 162:1658-64
Maestripieri, Dario; Lindell, Stephen G; Ayala, Alejandro et al. (2005) Neurobiological characteristics of rhesus macaque abusive mothers and their relation to social and maternal behavior. Neurosci Biobehav Rev 29:51-7
Angeloni, Stephen V; Glynn, Nicole; Ambrosini, Grazia et al. (2004) Characterization of the rhesus monkey ghrelin gene and factors influencing ghrelin gene expression and fasting plasma levels. Endocrinology 145:2197-205
Ayala, Alejandro R; Pushkas, Judy; Higley, J Dee et al. (2004) Behavioral, adrenal, and sympathetic responses to long-term administration of an oral corticotropin-releasing hormone receptor antagonist in a primate stress paradigm. J Clin Endocrinol Metab 89:5729-37
Gustavsson, Gunnar; Traskman-Bendz, Lil; Higley, J Dee et al. (2003) CSF testosterone in 43 male suicide attempters. Eur Neuropsychopharmacol 13:105-9
Bastian, Meredith L; Sponberg, Anne C; Sponberg, Anne C et al. (2003) Long-term effects of infant rearing condition on the acquisition of dominance rank in juvenile and adult rhesus macaques (Macaca mulatta). Dev Psychobiol 42:44-51
Heinz, A; Jones, D W; Gorey, J G et al. (2003) Serotonin transporter availability correlates with alcohol intake in non-human primates. Mol Psychiatry 8:231-4
Anderson, George M; Bennett, Allyson J; Weld, Katherine P et al. (2002) Serotonin in cisternal cerebrospinal fluid of rhesus monkeys: basal levels and effects of sertraline administration. Psychopharmacology (Berl) 161:95-9

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