Abstract

The goal is to use genes determining genetic variants of the electroencephalogram (EEG) and evoked responses of the EEG and to identify vulnerability genes for alcoholism and related behaviors with genetic components. This initiative is being pursued by: 1) family transmission and association studies on families identified by a population-based survey for probands with EEG variants. 2) a genetic linkage study to map the genes determining the variants. In the genetic epidemiological study, the low voltage alpha (LVA), EEG variant was confirmed to be transmitted in autosomal dominant fashion at least in some families. Alcoholism and anxiety disorders were more frequent in individuals with the LVA trait, identifying a more homogeneous subgroup of alcoholics with a genetic vulnerability. Families with the LVA variant and alcoholism have been collected and families are being analyzed for genetic linkage to dispersed and candidate gene DNA and protein markers.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Intramural Research (Z01)
Project #
1Z01AA000280-04
Application #
3767580
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
4
Fiscal Year
1993
Total Cost
Indirect Cost

  Institution

Name
National Institute on Alcohol Abuse and Alcoholism
Department
Type
DUNS #
City
State
Country
United States
Zip Code

  Publications

Jung, Y; Goldman, D (2018) Role of RNA modifications in brain and behavior. Genes Brain Behav 17:e12444
Reilly, Matthew T; Noronha, Antonio; Goldman, David et al. (2017) Genetic studies of alcohol dependence in the context of the addiction cycle. Neuropharmacology 122:3-21
Goldman, David (2014) The missing heritability of behavior: the search continues. Psychophysiology 51:1327-8
Zhou, Zhifeng; Enoch, Mary-Anne; Goldman, David (2014) Gene expression in the addicted brain. Int Rev Neurobiol 116:251-73
Ho, M K; Goldman, D; Heinz, A et al. (2010) Breaking barriers in the genomics and pharmacogenetics of drug addiction. Clin Pharmacol Ther 88:779-91
Araya, Ricardo; Hu, Xianzhang; Heron, Jon et al. (2009) Effects of stressful life events, maternal depression and 5-HTTLPR genotype on emotional symptoms in pre-adolescent children. Am J Med Genet B Neuropsychiatr Genet 150B:670-82
Enoch, Mary-Anne; White, Kenneth V; Waheed, Juwaria et al. (2008) Neurophysiological and genetic distinctions between pure and comorbid anxiety disorders. Depress Anxiety 25:383-92
Reuter, Martin; Jeste, Neelum; Klein, Thomas et al. (2007) Association of THR105Ile, a functional polymorphism of histamine N-methyltransferase (HNMT), with alcoholism in German Caucasians. Drug Alcohol Depend 87:69-75
Enoch, Mary-Anne; Shen, Pei-Hong; Xu, Ke et al. (2006) Using ancestry-informative markers to define populations and detect population stratification. J Psychopharmacol 20:19-26
Enoch, Mary-Anne; Waheed, Juwaria F; Harris, Claudia R et al. (2006) Sex differences in the influence of COMT Val158Met on alcoholism and smoking in plains American Indians. Alcohol Clin Exp Res 30:399-406

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