Abstract

The Baltimore Longitudinal Study of Aging (BLSA), the NIA's major research program on human aging has been conducted at the Gerontology Research Center since 1958. The overall scientific goals of the BLSA are: To identify differences among individuals of different ages and changes that occur in the serial observations of these individuals with the passage of time; to determine the relative contribution of aging, disease processes, cohort effects and secular effects in producing observed differences and changes; and to establish the degree of interrelation and/or interaction among these factors. To expand scientific understanding about predictors and risk factors for specific diseases and for other end points related to successes and failures of adaptation to aging processes. Scientists working with BLSA are assigned to 11 sections of 7 laboratories in addition of the LSB. The Chief, LSB is the Director of the BLSA and LSB staff administer and manage the BLSA as well as conduct research with it.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Intramural Research (Z01)
Project #
1Z01AG000015-33
Application #
3802182
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
33
Fiscal Year
1991
Total Cost
Indirect Cost

  Institution

Name
National Institute on Aging
Department
Type
DUNS #
City
State
Country
United States
Zip Code

  Publications

Agrawal, A; Chou, Y-L; Carey, C E et al. (2018) Genome-wide association study identifies a novel locus for cannabis dependence. Mol Psychiatry 23:1293-1302
Meier, Helen C S; Sandler, Dale P; Simonsick, Eleanor M et al. (2016) Association between Vitamin D Deficiency and Antinuclear Antibodies in Middle-Aged and Older U.S. Adults. Cancer Epidemiol Biomarkers Prev 25:1559-1563
Cheng, Yu-Ching; Stanne, Tara M; Giese, Anne-Katrin et al. (2016) Genome-Wide Association Analysis of Young-Onset Stroke Identifies a Locus on Chromosome 10q25 Near HABP2. Stroke 47:307-16
Jerome, Gerald J; Ko, Seung-uk; Kauffman, Danielle et al. (2015) Gait characteristics associated with walking speed decline in older adults: results from the Baltimore Longitudinal Study of Aging. Arch Gerontol Geriatr 60:239-43
Malik, Rainer; Freilinger, Tobias; Winsvold, Bendik S et al. (2015) Shared genetic basis for migraine and ischemic stroke: A genome-wide analysis of common variants. Neurology 84:2132-45
Milaneschi, Yuri; Sutin, Angelina R; Terracciano, Antonio et al. (2014) The association between leptin and depressive symptoms is modulated by abdominal adiposity. Psychoneuroendocrinology 42:1-10
Becker, Robert E; Greig, Nigel H; Giacobini, Ezio et al. (2014) A new roadmap for drug development for Alzheimer's disease. Nat Rev Drug Discov 13:156
Traylor, Matthew; Mäkelä, Kari-Matti; Kilarski, Laura L et al. (2014) A novel MMP12 locus is associated with large artery atherosclerotic stroke using a genome-wide age-at-onset informed approach. PLoS Genet 10:e1004469
Ay, Hakan; Arsava, Ethem Murat; Andsberg, Gunnar et al. (2014) Pathogenic ischemic stroke phenotypes in the NINDS-stroke genetics network. Stroke 45:3589-96
Malik, Rainer; Bevan, Steve; Nalls, Michael A et al. (2014) Multilocus genetic risk score associates with ischemic stroke in case-control and prospective cohort studies. Stroke 45:394-402

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