Abstract

This project uses participants in the Baltimore Longitudinal Study of Aging (BLSA) to gain insight into the biochemical and molecular mechanisms underlying age-associated changes in human immune function. Recent data suggests that human T lymphocytes activated through different cellular pathways display distinctive patterns of protein phosphorylation, cytokine synthesis and gene expression, only some of which are age-affected. With increasing age, an increasing large proportion of T-cells undergo cytokine-mediated apotosis.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Intramural Research (Z01)
Project #
1Z01AG000104-19
Application #
5200274
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
19
Fiscal Year
1995
Total Cost
Indirect Cost

  Institution

Name
National Institute on Aging
Department
Type
DUNS #
City
State
Country
United States
Zip Code

  Publications

Lustig, Ana; Carter, Arnell; Bertak, Dorothy et al. (2009) Transcriptome analysis of murine thymocytes reveals age-associated changes in thymic gene expression. Int J Med Sci 6:51-64
Nguyen, Dzung H; Taub, Dennis (2002) Cholesterol is essential for macrophage inflammatory protein 1 beta binding and conformational integrity of CC chemokine receptor 5. Blood 99:4298-306
Nguyen, Dzung H; Taub, Dennis (2002) CXCR4 function requires membrane cholesterol: implications for HIV infection. J Immunol 168:4121-6
Mascarucci, Paolo; Taub, Dennis; Saccani, Simona et al. (2002) Cytokine responses in young and old rhesus monkeys: effect of caloric restriction. J Interferon Cytokine Res 22:565-71
Mascarucci, P; Taub, D; Saccani, S et al. (2001) Age-related changes in cytokine production by leukocytes in rhesus monkeys. Aging (Milano) 13:85-94
Kalehua, A N; Taub, D D; Baskar, P V et al. (2000) Aged mice exhibit greater mortality concomitant to increased brain and plasma TNF-alpha levels following intracerebroventricular injection of lipopolysaccharide. Gerontology 46:115-28
Alexandroff, A B; Jackson, A M; Paterson, T et al. (2000) Role for CD40-CD40 ligand interactions in the immune response to solid tumours. Mol Immunol 37:515-26
Murphy, W J; Funakoshi, S; Fanslow, W C et al. (1999) CD40 stimulation promotes human secondary immunoglobulin responses in HuPBL-SCID chimeras. Clin Immunol 90:22-7
Kirken, R A; Erwin, R A; Taub, D et al. (1999) Tyrphostin AG-490 inhibits cytokine-mediated JAK3/STAT5a/b signal transduction and cellular proliferation of antigen-activated human T cells. J Leukoc Biol 65:891-9
Janik, J E; Miller, L L; Kopp, W C et al. (1999) Treatment with tumor necrosis factor-alpha and granulocyte-macrophage colony-stimulating factor increases epidermal Langerhans' cell numbers in cancer patients. Clin Immunol 93:209-21

Showing the most recent 10 out of 11 publications