Abstract

The purpose of this project is to assess the effects of aging at a behavioral level of analysis in animal models, to identify neurobiological mechanisms associated with these effects, and to test interventions which might alter age-related performance decrements. Rodent models are tested in a battery of sensori-motor and learning/memory tasks. Neurochemical lesions and assays are conducted to determine neurobiological correlates of functional losses. Interventions include dietary restriction, environmental enrichment, and various pharmacologic treatments. Multiple genotypes are examined to determine possible genetic involvement in the pattern of age-related behavioral impairment.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Intramural Research (Z01)
Project #
1Z01AG000302-03
Application #
3823200
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
3
Fiscal Year
1986
Total Cost
Indirect Cost

  Institution

Name
Aging
Department
Type
DUNS #
City
State
Country
United States
Zip Code

  Publications

Ahmet, Ismayil; Spangler, Edward; Shukitt-Hale, Barbara et al. (2009) Blueberry-enriched diet protects rat heart from ischemic damage. PLoS One 4:e5954
Komatsu, Toshimitsu; Chiba, Takuya; Yamaza, Haruyoshi et al. (2008) Manipulation of caloric content but not diet composition, attenuates the deficit in learning and memory of senescence-accelerated mouse strain P8. Exp Gerontol 43:339-46
Duffy, Kara B; Spangler, Edward L; Devan, Bryan D et al. (2008) A blueberry-enriched diet provides cellular protection against oxidative stress and reduces a kainate-induced learning impairment in rats. Neurobiol Aging 29:1680-9
Hyun, Dong-Hoon; Hunt, Nicole D; Emerson, Scott S et al. (2007) Up-regulation of plasma membrane-associated redox activities in neuronal cells lacking functional mitochondria. J Neurochem 100:1364-74
Jamieson, H A; Cogger, V C; Twigg, S M et al. (2007) Alterations in liver sinusoidal endothelium in a baboon model of type 1 diabetes. Diabetologia 50:1969-76
Devan, Bryan D; Pistell, Paul J; Daffin Jr, Lee W et al. (2007) Sildenafil citrate attenuates a complex maze impairment induced by intracerebroventricular infusion of the NOS inhibitor Nomega-nitro-L-arginine methyl ester. Eur J Pharmacol 563:134-40
Mattison, Julie A; Roth, George S; Lane, Mark A et al. (2007) Dietary restriction in aging nonhuman primates. Interdiscip Top Gerontol 35:137-58
Lane, Mark A; Roth, George S; Ingram, Donald K (2007) Caloric restriction mimetics: a novel approach for biogerontology. Methods Mol Biol 371:143-9
Carlson, Olga; Martin, Bronwen; Stote, Kim S et al. (2007) Impact of reduced meal frequency without caloric restriction on glucose regulation in healthy, normal-weight middle-aged men and women. Metabolism 56:1729-34
Zou, Sige; Sinclair, Jason; Wilson, Mark A et al. (2007) Comparative approaches to facilitate the discovery of prolongevity interventions: effects of tocopherols on lifespan of three invertebrate species. Mech Ageing Dev 128:222-6

Showing the most recent 10 out of 67 publications