Abstract

The purpose of this project is to assess the effects of aging at a behavioral level of analysis, to identify neurobiological mechanisms associated with these effects, and to test interventions that might alter age-related performance decrements. Rodent models are tested in a battery of sensorimotor and learning/memory tasks. Neurochemical and neurohistological assays are conducted to determine neurobiological correlates of functional losses. Interventions include dietary restriction, exercise, various pharmacologic treatments, neurotrophic factors and gene transfer via adenoviral vectors. Multiple genotypes are examined to determine possible genetic involvement in the pattern of age-related behavioral impairment.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Intramural Research (Z01)
Project #
1Z01AG000302-11
Application #
3745470
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
11
Fiscal Year
1994
Total Cost
Indirect Cost

  Institution

Name
National Institute on Aging
Department
Type
DUNS #
City
State
Country
United States
Zip Code

  Publications

Ahmet, Ismayil; Spangler, Edward; Shukitt-Hale, Barbara et al. (2009) Blueberry-enriched diet protects rat heart from ischemic damage. PLoS One 4:e5954
Komatsu, Toshimitsu; Chiba, Takuya; Yamaza, Haruyoshi et al. (2008) Manipulation of caloric content but not diet composition, attenuates the deficit in learning and memory of senescence-accelerated mouse strain P8. Exp Gerontol 43:339-46
Duffy, Kara B; Spangler, Edward L; Devan, Bryan D et al. (2008) A blueberry-enriched diet provides cellular protection against oxidative stress and reduces a kainate-induced learning impairment in rats. Neurobiol Aging 29:1680-9
Lane, Mark A; Roth, George S; Ingram, Donald K (2007) Caloric restriction mimetics: a novel approach for biogerontology. Methods Mol Biol 371:143-9
Carlson, Olga; Martin, Bronwen; Stote, Kim S et al. (2007) Impact of reduced meal frequency without caloric restriction on glucose regulation in healthy, normal-weight middle-aged men and women. Metabolism 56:1729-34
Zou, Sige; Sinclair, Jason; Wilson, Mark A et al. (2007) Comparative approaches to facilitate the discovery of prolongevity interventions: effects of tocopherols on lifespan of three invertebrate species. Mech Ageing Dev 128:222-6
O'Neil, Jahn N; Mouton, Peter R; Tizabi, Yousef et al. (2007) Catecholaminergic neuronal loss in locus coeruleus of aged female dtg APP/PS1 mice. J Chem Neuroanat 34:102-7
LE Couteur, David G; Cogger, Victoria C; McCuskey, Robert S et al. (2007) Age-related changes in the liver sinusoidal endothelium: a mechanism for dyslipidemia. Ann N Y Acad Sci 1114:79-87
Zhu, Min; Lee, Garrick D; Ding, Liusong et al. (2007) Adipogenic signaling in rat white adipose tissue: modulation by aging and calorie restriction. Exp Gerontol 42:733-44
Zahn, Jacob M; Poosala, Suresh; Owen, Art B et al. (2007) AGEMAP: a gene expression database for aging in mice. PLoS Genet 3:e201

Showing the most recent 10 out of 67 publications