Abstract

The purpose of this project is to assess the effects of aging at a behavioral level of analysis, to identify neurobiological mechanisms associated with these effects, and to test interventions that might alter age-related performance decrements. Rodent models are tested in a battery of sensorimotor and learning/memory tasks. Neurochemical and neurohistological assays are conducted to determine neurobiological correlates of functional losses. Interventions include dietary restriction, exercise, various pharmacologic treatments, neurotrophic factors and gene transfer via adenoviral vectors. Multiple genotypes are examined to determine possible genetic involvement in the pattern of age-related behavioral impairment.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Intramural Research (Z01)
Project #
1Z01AG000302-12
Application #
5200295
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
12
Fiscal Year
1995
Total Cost
Indirect Cost

  Institution

Name
National Institute on Aging
Department
Type
DUNS #
City
State
Country
United States
Zip Code

  Publications

Ahmet, Ismayil; Spangler, Edward; Shukitt-Hale, Barbara et al. (2009) Blueberry-enriched diet protects rat heart from ischemic damage. PLoS One 4:e5954
Komatsu, Toshimitsu; Chiba, Takuya; Yamaza, Haruyoshi et al. (2008) Manipulation of caloric content but not diet composition, attenuates the deficit in learning and memory of senescence-accelerated mouse strain P8. Exp Gerontol 43:339-46
Duffy, Kara B; Spangler, Edward L; Devan, Bryan D et al. (2008) A blueberry-enriched diet provides cellular protection against oxidative stress and reduces a kainate-induced learning impairment in rats. Neurobiol Aging 29:1680-9
Zhu, Min; Lee, Garrick D; Ding, Liusong et al. (2007) Adipogenic signaling in rat white adipose tissue: modulation by aging and calorie restriction. Exp Gerontol 42:733-44
Zahn, Jacob M; Poosala, Suresh; Owen, Art B et al. (2007) AGEMAP: a gene expression database for aging in mice. PLoS Genet 3:e201
Jamieson, Hamish A; Hilmer, Sarah N; Cogger, Victoria C et al. (2007) Caloric restriction reduces age-related pseudocapillarization of the hepatic sinusoid. Exp Gerontol 42:374-8
Pistell, Paul J; Daffin Jr, Lee W; Nelson, Christopher M et al. (2007) Combined administration of subthreshold doses of the nitric oxide inhibitor, nitro-L-arginine, and muscarinic receptor antagonist, scopolamine, impairs complex maze learning in rats. Behav Pharmacol 18:801-5
Utsuki, Tadanobu; Uchimura, Nao; Irikura, Mitsuru et al. (2007) Preclinical investigation of the topical administration of phenserine: transdermal flux, cholinesterase inhibition, and cognitive efficacy. J Pharmacol Exp Ther 321:353-61
Navas, Placido; Villalba, Jose Manuel; de Cabo, Rafael (2007) The importance of plasma membrane coenzyme Q in aging and stress responses. Mitochondrion 7 Suppl:S34-40
Hyun, Dong-Hoon; Hunt, Nicole D; Emerson, Scott S et al. (2007) Up-regulation of plasma membrane-associated redox activities in neuronal cells lacking functional mitochondria. J Neurochem 100:1364-74

Showing the most recent 10 out of 67 publications