NMR Studies of Aging in Cells, Organs, and Animals

Spencer, R G.

Abstract

NMR spectroscopy is currently being used at the NIA to study the phosphorus metabolism of peripheral muscle in BLSA subjects and other volunteers, as well as in animals. Age-related and exercise-related effects are under investigation. Methodologic studies to further develop kinetic and spin-lattice relaxation time measurement methodology are also being actively pursued.

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute on Aging (NIA)
• Type: Intramural Research (Z01)
• Project #: 1Z01AG000381-04
• Application #: 3745482
• Support Year: 4
• Fiscal Year: 1994

Institution

• Name: National Institute on Aging
• Country: United States

Publications

Bouhrara, Mustapha; Bonny, Jean-Marie; Ashinsky, Beth G et al. (2017) Noise Estimation and Reduction in Magnetic Resonance Imaging Using a New Multispectral Nonlocal Maximum-likelihood Filter. IEEE Trans Med Imaging 36:181-193

Ashinsky, Beth G; Bouhrara, Mustapha; Coletta, Christopher E et al. (2017) Predicting early symptomatic osteoarthritis in the human knee using machine learning classification of magnetic resonance images from the osteoarthritis initiative. J Orthop Res 35:2243-2250

Cameron, Donnie; Bouhrara, Mustapha; Reiter, David A et al. (2017) The effect of noise and lipid signals on determination of Gaussian and non-Gaussian diffusion parameters in skeletal muscle. NMR Biomed 30:

Bouhrara, Mustapha; Reiter, David A; Spencer, Richard G (2015) Bayesian analysis of transverse signal decay with application to human brain. Magn Reson Med 74:785-802

Irrechukwu, Onyi N; Thaer, Sarah Von; Frank, Eliot H et al. (2014) Prediction of cartilage compressive modulus using multiexponential analysis of T(2) relaxation data and support vector regression. NMR Biomed 27:468-77

Reiter, David A; Roque, Remigio A; Lin, Ping-Chang et al. (2011) Improved specificity of cartilage matrix evaluation using multiexponential transverse relaxation analysis applied to pathomimetically degraded cartilage. NMR Biomed 24:1286-94

Lin, Ping-Chang; Reiter, David A; Spencer, Richard G (2009) Classification of degraded cartilage through multiparametric MRI analysis. J Magn Reson 201:61-71

Ramaswamy, Sharan; Wang, Dong-An; Fishbein, Kenneth W et al. (2006) An analysis of the integration between articular cartilage and nondegradable hydrogel using magnetic resonance imaging. J Biomed Mater Res B Appl Biomater 77:144-8

Spencer, Richard G; Fishbein, Kenneth W; Cheng, Aiwu et al. (2006) Compatibility of Gd-DTPA perfusion and histologic studies of the brain. Magn Reson Imaging 24:27-31

Canuto, Holly C; Oliveira, Miguel L R; Fishbein, Kenneth W et al. (2006) Tendon and neurovascular bundle displacement in the palm with hand flexion and extension: an MRI and gross anatomy correlative study. J Magn Reson Imaging 23:742-6