Abstract

Increased concentrations of endogenous digitalis-like sodium pump inhibitors have been observed in chronic hypertension in humans and laboratory animals, but whether they are a cause or effect of the hypertension remains to be clarified. Digitalis-like factors might constitute a previously unrecognized group of stress hormones that could contribute to the development of human hypertension via interaction with dietary sodium intake. The present research tests the hypothesis that the blood pressure elevations occurring in micropigs during behavioral stress are mediated by increases in circulating levels of endogenous digitalis-like factors and inhibition of erythrocyte sodium pump activity.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Intramural Research (Z01)
Project #
1Z01AG000609-03
Application #
5200324
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
3
Fiscal Year
1995
Total Cost
Indirect Cost

  Institution

Name
National Institute on Aging
Department
Type
DUNS #
City
State
Country
United States
Zip Code

  Publications

Fedorova, Larisa V; Raju, Vanamala; El-Okdi, Nasser et al. (2009) The cardiotonic steroid hormone marinobufagenin induces renal fibrosis: implication of epithelial-to-mesenchymal transition. Am J Physiol Renal Physiol 296:F922-34
Fedorova, Olga V; Simbirtsev, Andrey S; Kolodkin, Nikolai I et al. (2008) Monoclonal antibody to an endogenous bufadienolide, marinobufagenin, reverses preeclampsia-induced Na/K-ATPase inhibition and lowers blood pressure in NaCl-sensitive hypertension. J Hypertens 26:2414-25
Kennedy, David J; Elkareh, Jihad; Shidyak, Amjad et al. (2008) Partial nephrectomy as a model for uremic cardiomyopathy in the mouse. Am J Physiol Renal Physiol 294:F450-4
Bagrov, Alexei Y; Shapiro, Joseph I (2008) Endogenous digitalis: pathophysiologic roles and therapeutic applications. Nat Clin Pract Nephrol 4:378-92
Kashkin, Vladimir A; Zvartau, Edwin E; Fedorova, Olga V et al. (2008) Endogenous bufadienolide mediates pressor response to ethanol withdrawal in rats. Eur Neuropsychopharmacol 18:74-7
Anderson, David E; Fedorova, Olga V; Morrell, Christopher H et al. (2008) Endogenous sodium pump inhibitors and age-associated increases in salt sensitivity of blood pressure in normotensives. Am J Physiol Regul Integr Comp Physiol 294:R1248-54
Bagrov, Yakov Y; Manusova, Natalia B; Frolova, Elena V et al. (2007) Endogenous sodium pump inhibitors, diabetes mellitus and preeclampsia Preliminary observations and a hypothesis. Pathophysiology 14:147-51
Fedorova, Olga V; Zhuravin, Igor A; Agalakova, Natalia I et al. (2007) Intrahippocampal microinjection of an exquisitely low dose of ouabain mimics NaCl loading and stimulates a bufadienolide Na/K-ATPase inhibitor. J Hypertens 25:1834-44
Elkareh, Jihad; Kennedy, David J; Yashaswi, Belvadi et al. (2007) Marinobufagenin stimulates fibroblast collagen production and causes fibrosis in experimental uremic cardiomyopathy. Hypertension 49:215-24
Kennedy, David J; Vetteth, Sandeep; Periyasamy, Sankaridrug M et al. (2006) Central role for the cardiotonic steroid marinobufagenin in the pathogenesis of experimental uremic cardiomyopathy. Hypertension 47:488-95

Showing the most recent 10 out of 35 publications