Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Intramural Research (Z01)
Project #
1Z01AG000732-09
Application #
6969395
Study Section
(LMG)
Project Start
Project End
Budget Start
Budget End
Support Year
9
Fiscal Year
2004
Total Cost
Indirect Cost
Name
Aging
Department
Type
DUNS #
City
State
Country
United States
Zip Code
Gearhart, Patricia J; Lindahl, Tomas; Neuberger, Michael S (2009) Preface. Philos Trans R Soc Lond B Biol Sci 364:561-2
Saribasak, Huseyin; Rajagopal, Deepa; Maul, Robert W et al. (2009) Hijacked DNA repair proteins and unchained DNA polymerases. Philos Trans R Soc Lond B Biol Sci 364:605-11
Martomo, Stella A; Saribasak, Huseyin; Yokoi, Masayuki et al. (2008) Reevaluation of the role of DNA polymerase theta in somatic hypermutation of immunoglobulin genes. DNA Repair (Amst) 7:1603-8
Gearhart, Patricia J (2008) Response to ""Mutation frequency vs. mutation patterns: A comparison of the results in spleen and Peyer's patches"". DNA Repair (Amst) 7:1411-2
Heltemes-Harris, Lynn M; Gearhart, Patricia J; Ghosh, Paritosh et al. (2008) Activation-induced deaminase-mediated class switch recombination is blocked by anti-IgM signaling in a phosphatidylinositol 3-kinase-dependent fashion. Mol Immunol 45:1799-806
Alrefai, Rudaina H; Winter, David B; Bohr, Vilhelm A et al. (2007) Nucleotide excision repair in an immunoglobulin variable gene is less efficient than in a housekeeping gene. Mol Immunol 44:2800-5
Martomo, Stella A; Gearhart, Patricia J (2006) Somatic hypermutation: subverted DNA repair. Curr Opin Immunol 18:243-8
Martomo, Stella A; Yang, William W; Vaisman, Alexandra et al. (2006) Normal hypermutation in antibody genes from congenic mice defective for DNA polymerase iota. DNA Repair (Amst) 5:392-8
Gearhart, Patricia J (2006) Antibody wars: extreme diversity. J Immunol 177:4235-6
Wilson, Teresa M; Vaisman, Alexandra; Martomo, Stella A et al. (2005) MSH2-MSH6 stimulates DNA polymerase eta, suggesting a role for A:T mutations in antibody genes. J Exp Med 201:637-45

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