We find that alternations in data acquired at alternating flip angles from the perfused rat heart are eliminated by the O-DAM correction. Corresponding simulations demonstrate that accurate saturation correction can be performed when metabolite changes are modest. Using typical parameters, we find that, as expected, greater degrees of accuracy can be achieved for smaller fractional changes in PCr. A decrease in PCr of less than 12% permits accuracy in PCr/Pi measurement to within 20%. For TR = 2 s, PCr can decrease by over 50% with accuracy of the corrected ratio remaining within 20%. Simulation of an ischemia-reperfusion experiment indicates the high degree of accuracy obtainable except at times of rapid concentration changes. Thus, the O-DAM procedure may permit accurate monitoring of metabolite concentrations even in the setting of chemical exchange and T1 changes.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Intramural Research (Z01)
Project #
1Z01AG000926-01
Application #
7732355
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
1
Fiscal Year
2008
Total Cost
$108,847
Indirect Cost
Name
National Institute on Aging
Department
Type
DUNS #
City
State
Country
United States
Zip Code