Abstract

The goals of this project are to characterize the natural history of mucocutaneous herpes simplex virus infections in normal and immune-impaired patients. In particular, we focus on genital herpes and the impact of brief and chronic acyclovir treatments on the natural history and expression of disease, and the in vitro sensitivity of virus recovered from patients. We have attempted to characterize the incidence of asymptomatic virus shedding from the genital area and to ascertain whether acyclovir alters those rates. The first convenient and efficient model of reactivation of herpes simplex virus infections in humans involving ultraviolet light exposure to previously infected skin sites has been established, and should serve to expand our comprehension of the temporal events and factors involved in disease expression.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Intramural Research (Z01)
Project #
1Z01AI000058-13
Application #
3960427
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
13
Fiscal Year
1986
Total Cost
Indirect Cost

  Institution

Name
Niaid Extramural Activities
Department
Type
DUNS #
City
State
Country
United States
Zip Code

  Publications

Dropulic, Lesia K; Lederman, Howard M (2016) Overview of Infections in the Immunocompromised Host. Microbiol Spectr 4:
Fernandez, Kristen Heins; Bream, Matthew; Ali, Mir A et al. (2013) Investigation of molluscum contagiosum virus, orf and other parapoxviruses in lymphomatoid papulosis. J Am Acad Dermatol 68:1046-7
Tang, Shuang; Bertke, Andrea S; Patel, Amita et al. (2008) An acutely and latently expressed herpes simplex virus 2 viral microRNA inhibits expression of ICP34.5, a viral neurovirulence factor. Proc Natl Acad Sci U S A 105:10931-6
Wang, Kening; Mahalingam, Gowtham; Hoover, Susan E et al. (2007) Diverse herpes simplex virus type 1 thymidine kinase mutants in individual human neurons and Ganglia. J Virol 81:6817-26
Wang, Kening; Lau, Tsz Y; Morales, Melissa et al. (2005) Laser-capture microdissection: refining estimates of the quantity and distribution of latent herpes simplex virus 1 and varicella-zoster virus DNA in human trigeminal Ganglia at the single-cell level. J Virol 79:14079-87
Wang, K; Pesnicak, L; Guancial, E et al. (2001) The 2.2-kilobase latency-associated transcript of herpes simplex virus type 2 does not modulate viral replication, reactivation, or establishment of latency in transgenic mice. J Virol 75:8166-72
Marques, A R; Straus, S E; Fahle, G et al. (2001) Lack of association between HSV-1 DNA in the brain, Alzheimer's disease and apolipoprotein E4. J Neurovirol 7:82-3
Moriuchi, M; Moriuchi, H; Williams, R et al. (2000) Herpes simplex virus infection induces replication of human immunodeficiency virus type 1. Virology 278:534-40
Marques, A R; Straus, S E (2000) Herpes simplex type 2 infections--an update. Dis Mon 46:325-59
Lekstrom-Himes, J A; LeBlanc, R A; Pesnicak, L et al. (2000) Gamma interferon impedes the establishment of herpes simplex virus type 1 latent infection but has no impact on its maintenance or reactivation in mice. J Virol 74:6680-3

Showing the most recent 10 out of 12 publications