Mechanisms of Pathogenesis and Recovery From Friend Murine Leukemia Virus

Chesebro, B.

Abstract

Mechanisms of recovery from leukemia induced by retroviral infection have been studied in the Friend murine leukemia virus system. Viral genes in both the helper and defective components of Friend virus complex have been examined to determine their respective roles in generation of and recovery from erythroleukemia . In addition, host genes influencing the anti-viral immune response including those in the major histocompatibility complex (H-2A, E, D, and T) and non-MHC genes such as Rfv-3 have also been studied to identify the mechanisms of elimination of both virus and leukemia cells. In a separate aspect of the project retrovirus-induced brain disease has been studied using polytropic retroviruses derived from Friend murine leukemia virus. This work has focused on analysis of the cell specificity of virus infection and the pathology produced in the central nervous system. Furthermore, the role of various regions of the viral envelope gene in mediating disease has been studied using detailed mapping studies.

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Allergy and Infectious Diseases (NIAID)
• Type: Intramural Research (Z01)
• Project #: 1Z01AI000074-25
• Application #: 6160542
• Study Section: Special Emphasis Panel (LPVD)
• Support Year: 25
• Fiscal Year: 1997

Institution

• Name: National Institute of Allergy and Infectious Diseases
• Country: United States

Publications

Mehaffey, J Hunter; Michaels, Alex D; Mullen, Mathew G et al. (2017) Patient travel for bariatric surgery: does distance matter? Surg Obes Relat Dis 13:2027-2031

Michaels, Alex D; Mullen, Matthew G; Guidry, Christopher A et al. (2017) Unplanned Reoperation Following Colorectal Surgery: Indications and Operations. J Gastrointest Surg 21:1480-1485

Michaels, Alex D; Hunter Mehaffey, J; Brenton French, W et al. (2017) Hypoglycemia Following Bariatric Surgery: Our 31-Year Experience. Obes Surg 27:3118-3123

Mehaffey, J Hunter; Hawkins, Robert B; Mullen, Matthew G et al. (2017) Access to Quaternary Care Surgery: Implications for Accountable Care Organizations. J Am Coll Surg 224:525-529

Mullen, Matthew G; Salerno, Elise P; Michaels, Alex D et al. (2016) Declining Operative Experience for Junior-Level Residents: Is This an Unintended Consequence of Minimally Invasive Surgery? J Surg Educ 73:609-15

Brien, James D; Daffis, Stephane; Lazear, Helen M et al. (2011) Interferon regulatory factor-1 (IRF-1) shapes both innate and CD8(+) T cell immune responses against West Nile virus infection. PLoS Pathog 7:e1002230

Peterson, Karin E; Pourciau, Susan; Du, Min et al. (2008) Neurovirulence of polytropic murine retrovirus is influenced by two separate regions on opposite sides of the envelope protein receptor binding domain. J Virol 82:8906-10

Santiago, Mario L; Montano, Mauricio; Benitez, Robert et al. (2008) Apobec3 encodes Rfv3, a gene influencing neutralizing antibody control of retrovirus infection. Science 321:1343-6

Peterson, K E; Chesebro, B (2006) Influence of proinflammatory cytokines and chemokines on the neuropathogenesis of oncornavirus and immunosuppressive lentivirus infections. Curr Top Microbiol Immunol 303:67-95

Peterson, Karin E; Evans, Leonard H; Wehrly, Kathy et al. (2006) Increased proinflammatory cytokine and chemokine responses and microglial infection following inoculation with neural stem cells infected with polytropic murine retroviruses. Virology 354:143-53