Abstract

Mechanisms of retrovirus-induced brain pathogenesis have been studied using a murine polytropic retrovirus model where two closely related viruses differing in virulence were compared. Clinical brain disease was correlated with an increase in expression of several cytokines and beta-chemokines including TNF-alpha, TNF-beta, interleukin-1alpha, MIP-1alpha, MIP-1beta, MCP-1, IP-10 and RANTES. The increased expression of these genes occurred prior to clinical disease suggesting that they might be involved in induction of the pathogenic process. Two separate regions of the viral envelope gene were associated with disease in this model, but upregulation of cytokines and chemokines was associated with only one of these regions. The mechanism of action of the other region remains unknown, but may provide an opportunity to detect new pathogenic mechanisms of retrovirus-induced brain disease.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Intramural Research (Z01)
Project #
1Z01AI000074-29
Application #
6531608
Study Section
(LPVD)
Project Start
Project End
Budget Start
Budget End
Support Year
29
Fiscal Year
2001
Total Cost
Indirect Cost

  Institution

Name
Niaid Extramural Activities
Department
Type
DUNS #
City
State
Country
United States
Zip Code

  Publications

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Mehaffey, J Hunter; Michaels, Alex D; Mullen, Mathew G et al. (2017) Patient travel for bariatric surgery: does distance matter? Surg Obes Relat Dis 13:2027-2031
Michaels, Alex D; Mullen, Matthew G; Guidry, Christopher A et al. (2017) Unplanned Reoperation Following Colorectal Surgery: Indications and Operations. J Gastrointest Surg 21:1480-1485
Mullen, Matthew G; Salerno, Elise P; Michaels, Alex D et al. (2016) Declining Operative Experience for Junior-Level Residents: Is This an Unintended Consequence of Minimally Invasive Surgery? J Surg Educ 73:609-15
Brien, James D; Daffis, Stephane; Lazear, Helen M et al. (2011) Interferon regulatory factor-1 (IRF-1) shapes both innate and CD8(+) T cell immune responses against West Nile virus infection. PLoS Pathog 7:e1002230
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Peterson, K E; Chesebro, B (2006) Influence of proinflammatory cytokines and chemokines on the neuropathogenesis of oncornavirus and immunosuppressive lentivirus infections. Curr Top Microbiol Immunol 303:67-95
Peterson, Karin E; Evans, Leonard H; Wehrly, Kathy et al. (2006) Increased proinflammatory cytokine and chemokine responses and microglial infection following inoculation with neural stem cells infected with polytropic murine retroviruses. Virology 354:143-53

Showing the most recent 10 out of 24 publications