The merozoite interacts in a receptor specific manner with the erythrocyte surface and is the stage upon which immunity may work to block invasion. Thus, merozoite surface components are of interest because of their role in erythrocyte recognition and as antigens for induction of protective immunity. We are identifying P. knowlesi, P. vivax and P. falciparum receptors for attachment to monkey and human erythrocytes. To understand the molecular basis for this variation we are studying one antigen on the merozoite surface that undergoes antigenic variation. The components in the junction and the signaling after merozoites make contact with erythrocytes is also under study.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Intramural Research (Z01)
Project #
1Z01AI000241-10
Application #
3803119
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
10
Fiscal Year
1991
Total Cost
Indirect Cost
City
State
Country
United States
Zip Code
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